脱氢表雄酮对卵巢储备功能低下行体外受精-胚胎移植患者治疗结局的影响

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摘要目的探讨脱氢表雄酮(DHEA)对行体外受精-胚胎移植(IVF-ET)的卵巢储备功能低下(DOR)患者治疗结局的影响。方法将接受体外受精/卵胞浆内单精子注射(IVF/ICSI)治疗的169例DOR患者,分为DHEA治疗组(n=89)和对照组(n=80),DHEA治疗组均有1次IVF-ET失败经历。DHEA治疗前、后IVF周期相关指标行自身对照比较,并分别与同期对照组比较。结果 DHEA治疗前、后、对照组间基础LH、基础E₂、基础T比较,差异均无统计学意义;DHEA治疗组治疗前、后AFC、AMH比较,DHEA治疗组治疗后基础FSH、AMH与对照组比较,差异均有统计学意义。DHEA治疗组治疗前、后和对照组Gn总剂量、Gn使用天数、hCG日E₂之间比较,差异均无统计学意义;DHEA治疗组治疗后获卵数较治疗前升高,差异有统计学意义;DHEA治疗组治疗前、后优质胚胎数比较,以及分别与对照组比较,差异均有统计学意义。DHEA治疗组治疗前、后和对照组受精率、优质胚胎率、周期取消率之间比较,差异均无统计学意义;DHEA治疗组治疗后卵裂率、临床妊娠率较治疗升高,差异有统计学意义;DHEA治疗组治疗后流产率、多胎妊娠率、活产率与对照组比较,差异均无统计学意义。结论 DHEA辅助治疗可以改善重复周期的DOR患者卵巢储备功能,提高卵巢反应性,改善IVF治疗结局。

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关键词 ：脱氢表雄酮, 卵巢储备功能低下, 体外受精-胚胎移植

收稿日期: 2016-08-19

基金资助:广东省医学科研基金资助项目(A2013876)

通讯作者: 全松(quansongsum@163.com)

引用本文:

林秀峰,吴日然,杜静,全松. 脱氢表雄酮对卵巢储备功能低下行体外受精-胚胎移植患者治疗结局的影响[J]. 中国生育健康杂志, 2017, 28(2): 171-173.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2017/V28/I2/171

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