Abstract:Objective To assess the efficacy of supplementation with long-chain polyunsaturated fatty acid (LCPUFAs) on infant cerebral development by conducting a meta-analysis.Methods Literature search was performed in Pubmed, Medline, Science Online, EMBASE, CNKI, VIP, and Wangfang data as of May 2013 to obtain randomized controlled clinical trails that assessed the efficacy of LCPUFA supplementation in infant formula on the cerebral development. JADAD measuring scale was used to evaluate the methodological quality. The experimental group was defined as infants feeding on formulas with LCPUFAs supplementation, and the control group as infants feeding on control formulas without LCPUFAs. The testing results of Bayley Scales of Infant Development (BSID) at 12 and 18 months, Fagan Test of Infant Intelligence (FTII) at 12 months and MacArthur Communicative Development Inventories (MCDI) at 14 months were measured as efficacy index. RevMan 5.0 software was used for meta-analysis.Results Thirteen RCT trials involving 1577subjects were included according to the inclusion and exclusion criteria. Twelve trials reported both MDI and PDI with BSID. There were no significant difference between the two groups both in MDI and in PDI. Subgroup analyses were carried out for the preterm and term infants at both 12 and 18 months respectively. The MDI measured in the preterm at 18 months and the PDI measured in the term infant at 12 months had significant difference between two groups. No other subgroups showed significant difference in the MDI and PDI. The testing results of FTII and MCDI also showed no significant difference between groups.Conclusion This meta-analysis suggests that supplementation with LCPUFAs in infant formulas has no effect on cerebral development.
李雪,李勇,蔡夏夏,马小陶,张召锋. 配方奶粉添加长链多不饱和脂肪酸对婴幼儿大脑发育影响的Meta分析[J]. 中国生育健康杂志, 2014, 25(1): 6-13.
LI Xue, LI Yong, CAI Xiaxia, MA Xiaotao, ZHANG Zhaofeng. Effect of supplementation with long-chain polyunsaturated fatty acid on infant cerebral development: a meta-analysis. Chinese Journal of Reproductive Health, 2014, 25(1): 6-13.
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