新疆维吾尔族妇女宫颈癌高危型人乳头瘤病毒负荷量与宫颈病变的相关性研究

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摘要目的探讨新疆维吾尔族妇女宫颈癌高危型人乳头瘤病毒(HPV)负荷量与宫颈病变程度的关系。方法对在新疆自治区人民医院诊治的906例维吾尔族妇女进行宫颈液基细胞学检测,采用杂交捕获2代(HCⅡ)方法定量检测宫颈HPV-DNA负荷量,并在阴道镜下行宫颈多点活检和颈管诊刮术。按HPV-DNA负荷量＜1、1～、101～、501～、1 001～4 263组。结果 906例患者中宫颈炎、宫颈上皮内瘤变和宫颈癌分别为76.6 %、13.3 %和10.2 %,3者HPV-DNA负荷量总体分布比较,差异有统计学意义。HPV-DNA负荷量≥1时CIN及宫颈癌的阳性诊断率较＜1时显著升高,HPV-DNA负荷量＞100时,CIN及宫颈癌的阳性诊断率显著升高;随着HPV-DNA负荷量增加高宫颈癌的阳性率显著升高,差异均有统计学意义。结论 HPV-DNA负荷量随宫颈病变的严重程度而增加,可作为宫颈癌前病变及宫颈癌的筛查客观指标。

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关键词 ：人乳头瘤病毒负荷量, 液基细胞, 阴道镜, 宫颈病变

Abstract：Objective To explore the relation between human papillomavirus (HPV) DNA load and cervical intraepithelial neoplasia (CIN), and to assess the application of liquid-based cytology test(CCT) and high-risk human papillomavirus test in cervical lesion diagnosis.Methods A total of 906 women who received treatments in the People’s Hospital were included and received CCT and HPV DNA semi-quantitative determination by hybrid capture II (HC2II). Cervical biopsy was obtained under colposcopy and histopathologic tests were considered as the final diagnoses According to HPV-DNA loads, the patients were classified into five group: HPV<1, 1≤HPV≤100, 100<HPV≤500, 500<HPV≤1 000, and HPV>1 000, respectively.Results A total of 694 patients were identified as cervicitis, 120 cervical as intraepithelial neoplasia, and 92 as cervical cancer. There were significant differences in their HPV-DNA loads among the three groups. It was found that high HPV DNA load increased with aggravation of cervical diseases. The collectivity distribution of HPV quantity were significantly different among the three groups. The rate of having a diagnosis of cervical intraepithelial neoplasia was significantly higher among those with HPV DNA >100 than other groups. The rate of having a diagnosis of CIN II, CIN III and SCC were significantly higher among those with HPV DNA>1 than the rate among those with HPV DNA<1.Conclusion High HPV DNA load increased with aggravation of cervical diseases. HPV DNA load is an objective index to screen cervical lesion and cervical canner.

Key words： Human papillomavirus load Liquid-based cell Colposcopy Cervical lesions

收稿日期: 2013-04-05

基金资助:新疆维吾尔自治区人民医院院内项目(20100101)

引用本文:

焦桢,陆萍,隋霜,王琳. 新疆维吾尔族妇女宫颈癌高危型人乳头瘤病毒负荷量与宫颈病变的相关性研究[J]. 中国生育健康杂志, 2014, 25(1): 14-17.
JIAO Zhen, LU Ping, SUI Shuang, WANG Lin. The relation between human papillomavirus (HPV) DNA load and cervical intraepithelial neoplasia. Chinese Journal of Reproductive Health, 2014, 25(1): 14-17.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2014/V25/I1/14

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