Expression of progesterone-induced blocking factors and progesterone receptors in the maternal-fetal interface treated with mifepristone and misoprostol
Abstract：Objective To study the anti-early pregnancy mechanism of mifepristone and misoprostol by investigating the expression of progesterone-induced blocking factor (PIBF) and progesterone receptor (PR) in the maternal-fetal interface of early pregnancy.Methods PIBF and PR were investigated with immunohistochemistry in 3 groups, including group A (successful medical abortion, n=30), group B (failure medical abortion, n=30) and group C (induced abortion with vacuum aspiration, n=30).Results PIBF was mainly detected in the cytoplasm of syncytiotrophoblastic, cytotrophoblastic and decidual cells, and PR expressed on decidual cell nucleus. The expression of PIBF and PR in deciduas of group A and B was lower than group C, with no difference of PIBF expression in villus. Both PIBF and PR had lower expression level in group A than in group B.Conclusion Mifepristone may prevent pregnancy by lowering the expression of PIBF and PR in the maternal-fetal interface of early pregnancy, and the success rate of pregnancy was associated with the decline in their expression.
吴邵花,张弘,朱凌云,高爱华,邓立峰,董赟. 米非司酮配伍米索前列醇对母胎界面孕酮诱导阻断因子及孕酮受体表达的影响[J]. 中国生育健康杂志, 2014, 25(1): 33-36.
WU Shaohua, ZHANG Hong, ZHU Lingyun, GAO Aihua, DENG Lifeng, DONG Yun. Expression of progesterone-induced blocking factors and progesterone receptors in the maternal-fetal interface treated with mifepristone and misoprostol. Chinese Journal of Reproductive Health, 2014, 25(1): 33-36.
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