Abstract：Objective To identify risk factors of thrombocytopenia caused by the exchange transfusion in the treatment of neonates with severe hyperbilirubinemia.Methods A retrospective study was conducted among 528 neonates of the exchange transfusion in the treatment of severe hyperbilirubinemia. Of the treated neonates, 127 cases had thrombocytopenic after exchange transfusion (study group). 127 neonates with normal platelet count after treatment were randomly selected as controls. Risk factors of thrombocytopenia were explored.Results The rate of thrombocytopenia was as high as 24.05% after the exchange transfusion (127/528 cases). Among the 127 cases with thrombocytopenia, 89 patients (70.1%) had platelet of 50×109/L or higher, 31 patients (24.4%) had platelet of 20-50×109/L, and the remaining 7 (5.52%) had platelet <20×109/L. There were significant differences in age, total bilirubin, intracranial hemorrhage or cephalhematoma, and metabolic acidosis following blood exchange transfusion between the two groups.Conclusion Age, total bilirubin, intracranial hemorrhage or cephalhematoma, and metabolic acidosis following blood exchange transfusion were risk factors of thrombocytopenia caused by the exchange transfusion in the treatment of neonates with severe hyperbilirubinemia.
李翠莲,杨跃煌,刘红林,刘玲. 严重高胆红素血症新生儿换血治疗后血小板减少症的危险因素[J]. 中国生育健康杂志, 2017, 28(3): 233-236.
LI Cuilian, YANG Yuehuang, LIU Honglin, LIU Ling. Risk factors of neonatal thrombocytopenia after exchange transfusion. Chinese Journal of Reproductive Health, 2017, 28(3): 233-236.
