Abstract：Objective To characterize the variations of cord blood dendritic cells (DC) subset isolated from fetuses whose mothers had chronic hepatitis B (CHB), to examine the relationships between these variations and HBV load, and to elucidate the transmission mechanism of CHB from mothers to their babies.Methods We detected 28 cord blood samples from fetuses whose mothers had chronic hepatitis B for the DC subsets. All the cord blood samples were detected immediately after being collected, and the percentages of DC1 and DC2 were determined by three-color cytometry. The samples from fetuses whose mothers had chronic hepatitis B were centrifuged, and assessed for HBVDNA load.Results In all of the 28 samples of fetuses whose mothers had chronic hepatitis B, 12 was positive, and the others was negative. In the samples with HBV DNA positive, we found that the percentages of DC1 and DC2 were lower in cord blood whose HBV DNA was positive than it was negative.Conclusion Not all of the newborns were infected although their mothers had chronic hepatitis B. The relative quantity of the DC1 and DC2 in cord blood whose mothers had CHB was associated with HBV DNA level.
王秀娟, 张剑白. 慢性乙肝病毒感染产妇新生儿脐血树突状细胞亚群变化与乙肝病毒核酸载量的关系[J]. 中国生育健康杂志, 2014, 25(5): 399-402.
Department of Pediatrics, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Relationship between HBV DNA and cord blood dendritic cells subset isolated from fetuses whose mothers had chronic hepatitis B. Chinese Journal of Reproductive Health, 2014, 25(5): 399-402.
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