Abstract：Objective To evaluate the efficacy of Bicyclol Tablets in reducing and delaying the damage of liver using chemotherapy in treatment of cervical cancer.Methods 90 cases of cervical cancer patients who used chemotherapy were randomly divided into two groups. All patients had normal liver function before chemotherapy. Treatment group was prescribed oral Bicyclol Tablets 50mg, control group was prescribed oral glycyrrhizinate capsules 150mg. Both of them were prescribed 3 times a day. The liver function was checked every week after treatment. Difference of valley alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) were observed.Results All patients completed the chemotherapy treatment period, with some liver function damage in both groups. More serious damage was observed in the control group which need assisted intravenous hepatoprotective drug treatment to continue chemotherapy. The damage of liver was significantly lower in Bicyclol Tablets group than the control group. The control group had a higher incidence of grade III liver injury than the treatment group.Conclusion Bicyclol Tablets 150mg / D could effectively prevent and reduce the drug induced liver damage in chemotherapy.
邓建华,刘玉. 宫颈癌化疗期间双环醇片预防肝损害研究[J]. 中国生育健康杂志, 2017, 28(4): 330-332.
DENG Jianhua, LIU Yu. The study on prevention effect of Bicyclol to liver damage using chemotherapy in treatment of cervical cancer. Chinese Journal of Reproductive Health, 2017, 28(4): 330-332.
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