Fractalkine及其受体CX3CR1表达与宫颈癌临床病理特征的关系

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摘要目的检测宫颈癌血清中Fractalkine及其受体CX3CR1的表达,探讨Fractalkine及其受体CX3CR1在宫颈癌发生、发展中的作用。方法采用ELISA法检测宫颈癌患者40例(宫颈癌组)、宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)患者30例(CIN组)、正常健康人群20例(正常组)血清中Fractalkine及其受体CX3CR1表达,并对Fractalkine及其受体CX3CR1表达与宫颈癌临床病理特征之间的关系进行分析。结果宫颈癌组患者血清Fractalkine、CX3CR1表达水平均明显低于正常组及CIN组,差异有统计学意义;此外,CIN组LSIL患者血清Fractalkine表达水平[(4 228.1±214.4) pg/ml]明显高于HSIL患者[(3 438.1±411.0)pg/ml],CIN组LSIL患者血清CX3CR1表达水平[(31.4±4.4)pg/ml]明显高于HSIL患者[(27.0±2.0)pg/ml],差异均有统计学意义;宫颈癌伴有淋巴结转移组血清Fractalkine、CX3CR1表达水平均明显低于无淋巴结转移组,差异有统计学意义;宫颈癌血清Fractalkine和CX3CR1水平表达与宫颈癌FIGO分期、淋巴结转移有关(P<0.05)。Fractalkine及其受体CX3CR1在宫颈癌血清中的表达水平呈正相关(r_s=0.371,P=0.018)。结论 Fractalkine 及其受体CX3CR1的低表达与宫颈癌的侵袭和淋巴结转移密切相关,在宫颈癌发生发展过程中可能发挥了重要作用。

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	李堰松
	刘雪峰

关键词 ：宫颈癌, Fractalkine, CX3CR1

Abstract：Objective To investigate the expression of fractalkine and its receptor CX3CR1 in cervical cancer and to evaluate its clinical significance in the occurrence and development of cervical carcinoma. Methods The expression of fractalkine and its receptor CX3CR1 was determined by ELISA in 40 cervical cancer patients, 30 cervical intraepithelial neoplasia (CIN) patients, and 20 healthy women. The relationship of serum fractalkine and its receptor CX3CR1 levels and the clinicopathologic characteristics was analyzed.Results Serum fractalkine and CX3CR1 levels in the cervical cancer group were significantly lower than those in the healthy group and the CIN group (Ps<0.01). In the CIN group, serum level of fractalkine in patients of LSIL (4 228.1±214.4pg/ml) was higher than that of HSIL patients (3 438.1±411.0pg/ml) (P<0.01); serum level of CX3CR1 in patients of LSIL (31.4±4.4pg/ml) was higher than that of HSIL patients (27.0±2.0pg/ml) (P<0.05). Serum levels of fractalkine and CX3CR1 in the cervical cancer group with lymph node metastasis were significantly lower than those in the cervical cancer group without lymph node metastasis (P<0.05). The levels of fractalkine and CX3CR1 were closely related with tumor size, clinical stage, and lymph node metastasis (P<0.05). Fractalkine was linearly correlated with CX3CR1 (r_s=0.371, P=0.018).Conclusion The low expression of fractalkine and its receptor CX3CR1 may be correlated with invasion and lymph node metastasis of cervical cancer. Fractalkine and its receptor CX3CR1 may play an important role in the progress of cervical carcinoma.

Key words： Cervical cancer Fractalkine CX3CR1

收稿日期: 2015-12-09

通讯作者: 刘雪峰(Liuxf1970@126.com)

引用本文:

李堰松, 刘雪峰. Fractalkine及其受体CX3CR1表达与宫颈癌临床病理特征的关系[J]. 中国生育健康杂志, 2016, 27(4): 340-343.
LI Yansong, LIU Xuefeng. The relation between expression of fractalkine and its receptor CX3CR1 and clinicopathologic features in cervical cancer. Chinese Journal of Reproductive Health, 2016, 27(4): 340-343.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2016/V27/I4/340

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