Abstract：Objective To evaluate the efficacy of nasal intermittent positive pressure ventilation (NIPPV) in treating infants with apnea of prematurity (AOP).Methods Preterm infants admitted to our neonatal intensive care unit between November 2013 and June 2015 and met the inclusion criteria were included. The subjects were randomly divided into NIPPV group and nasal continuous positive airway pressure (NCPAP) group. Arterial blood gas and PaO2 /FiO2(OI) before ventilation and 2 and 48 hours after noninvasive ventilation, the ventilation time, and complications were compared between the two groups.Results A total of 62 of infants, 33 in the NIPPV group and 29 in the NCPAP group, were included. Before ventilation, there was no statistically significant difference in pH [(7.275±0.104) vs. (7.260±0.095)], PaO2[(50.6±11.2) vs. (46.6±11.2) mmHg], PaCO2[(49.6±12.8) vs. (54.5±11.3) mmHg], and OI [(213±62) vs. (188±65)] between the two groups. However, the difference was statistically significant between the two groups in pH [(7.402±0.034) vs. (7.323±0.089)], PaO2[(81.3±14.6) vs. (62.5±8.0) mmHg], PaCO2[(38.1±5.6) vs. (44.0±9.6) mmHg], and OI[(333±86) vs. (262±57)] 2 hours after noninvasive ventilation. The difference was statistically significant between the two groups in pH [(7.419±0.029) vs. (7.363±0.052)], PaO2[(79.9±10.4) vs. (68.7±15.4) mmHg], PaCO2[(37.1±6.1) vs. (40.2±5.6) mmHg], and OI [(370±59) vs. (316±76)] 48 hours after noninvasive ventilation. The total effective rate in the NIPPV group (69.7%) was significantly higher than that in the NCPAP group (34.5%). The noninvasive respiratory support time [(3.6±3.3)d] and oxygen supply time [(1.5±1.6)d] in the NIPPV group were shorter than those in the NCPAP group [(7.8±9.4)d and (6.4±10.0)d, respectively]; the difference was statistically significant. There was no statistically significant difference in the proportion of aminophylline use (57.6% vs. 55.2%), the proportion of the invasive respiratory support (9.1% vs. 3.4%), the length of hospital stay [(34.8±20.1)d vs.(30.5±16.9)d], and the incidence of bronchopulmonary dysplasia (9.1% vs. 17.2%) between the two groups.Conclusion NIPPV was more efficacious than NCPAP in treating AOP, as evidenced by reduced respiratory support and oxygen without increasing side effects.
蔡琳, 李晓东, 刘丽芳, 张升荣. 经鼻间歇正压通气治疗早产儿呼吸暂停的疗效观察[J]. 中国生育健康杂志, 2016, 27(6): 529-533.
CAI Lin, LI Xiaodong, LIU Lifang, ZHANG Shengrong. Efficacy of nasal intermittent positive pressure ventilation for treatment of infants with apnea of prematurity. Chinese Journal of Reproductive Health, 2016, 27(6): 529-533.
