妊娠期睡眠呼吸障碍暴露对后代神经行为发育的潜在危害

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摘要随着妊娠的进展,睡眠呼吸障碍(Sleep-Disordered Breathing,SDB)的发生率逐步上升且症状逐渐加重,是导致母亲和胎儿不良分娩结局的重要危险因素。动物实验表明孕期缺氧可使仔代脑体积变小,海马和小脑的神经元数目减少,学习记忆能力下降。人脑结构极为复杂,胎脑对缺氧有一定的自我保护机制,出生后又存在追赶生长,故孕期SDB对婴幼儿神经行为发育的影响十分复杂。本文从基础医学、动物实验、现有的流行病学调查和临床研究等方面寻找妊娠期SDB暴露对后代脑发育潜在危害的证据,为今后进一步开展临床研究和早期干预提供参考。

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	雷洁
	李生慧

关键词 ：妊娠期, SDB, 儿童, 神经行为

收稿日期: 2017-06-16

基金资助:国家自然科学基金面上项目(81673183);2012年度上海市公共卫生优秀学科带头人培养计划(GWDTR201222);江苏省高等职业院校教师专业带头人高端研修项目(2016GRFX053)

通讯作者: 李生慧(lsh9907@163.com)

引用本文:

雷洁,李生慧. 妊娠期睡眠呼吸障碍暴露对后代神经行为发育的潜在危害[J]. 中国生育健康杂志, 2018, 29(5): 480-484.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2018/V29/I5/480

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