Observation on the contraceptive effect of a new stereoscopic intrauterine device for rhesus macaques
YU Ling, ZHANG Meihua, ZHAI Liping, LI Zhixiong, YU Jianchun, QIU Yi
Key Laboratory of Birth Regulation and Control Technology of National Health and Family Planning Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, Shandong Provincial Family Planning Institute of Science and Technology, Shandong 250014, China
Abstract：Objective To develop and observe the contraceptive effect of a new stereoscopic intrauterine device (SIUD) and the change of endometrial in adult female Rhesus macaque.Methods The scaffold of SIUD used in rhesus macaque was made of nickel-titanium memory alloy wires and woven into a grid-shaped, covered the layer of silicone rubber. 18 Adult female Rhesus macaques were selected for external measurement of uterus, ovary and oviducts in the Fujian provincial family planning science and Technology Institute, primate experimental base in Fuzhou, Fujian. The SIUD (experimental) group (n=9) and control group (n=9) were divided.Results The stent of Rhesus macaque SIUD was heart-shaped or inverted pear-shaped, the length of the upper, lower diameter and height was 0.6~0.8 cm, 0.3~0.4 cm and 0.6~1.2 cm respectively with the thickness 0.2~0.3 cm. The Ni-Ti memory alloy stent was reduced to a straight line below 25 ℃, and its structure was restored at the body temperature of 36~37℃. The silicone rubber coating prevented the adhesion between NiTi alloy wire and tissue. The external measurement including the length, width and thickness was (27.1±2.1) mm, (20.8±2.4) mm and (17.5±2.1) mm respectively for uterus, and (9.5±0.9) mm, (7.3±0.7) mm and (7.1±7.1) mm respectively for ovary, and the length of fallopian tube was (4.2±0.6)cm. Nine rhesus macaque in experimental group were successfully inserted in a new SIUD, and 1 of them was fell off in 3 months, all other eight SIUD did not fell off and the macaques were not pregnant, with the rate of shedding and pregnant was 11.1% (1/9). All nine rhesus macaques in control group were pregnant (P<0.05).ConclusionThe shape of Rhesus macaque was similar to that of human beings, and it’s a good animal model for the development of a new SIUD. Our study showed that SIUD has a good contraceptive effect in Rhesus macaque.
