1 Furtunescu F,Dosius M,Ltea RE,et al.Evaluation of endometrial cancer epidemiology in Romania.Med Life,2015,8:218-225. 2 Fan D,Ma C,Zhang H.The molecular mechanisms that under Lie the tumor suppressor function of LKB1. Acta Biochim BioPhys Sin,2009,41:97-107. 3 Zhao ZY,Jiang YL,Li BR,et al. A novel mutation (c.855delG) in STK11 gene is associated with Peutz-Jeghers syndrome in a Chinese family.Digest Liver Dis,2018,50:312-314. 4 Hearle N,Schumacher V,Menko FH,et al.Frequency and spectrum of cancers in the Peutz-Jeghers syndrome.Clin Cancer Res,2006,12:3209-3215. 5 Mehellou Y,Alessi DR,Macartney TJ,et al.Stuctural insights into the activation of MST3 by MO25.Biochem Biophys Res Commun,2013,432:604-609. 6 Gaude H,Aznar N,Delay A,et al.Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. Oncogene,2012,31:1582-1591. 7 Swisa A,Granot Z,Tamarina N,et al.Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion DespiteProfound Mitochondrial Defects.J Biol Chem,2015,290:20934-20946. 8 Korsse SE,Peppelenbosch MP,Veelen W.Targeting LKB1 signaling in cancer.Biochim Biophys Acta,2013,1835:194-210. 9 Gan RY,Li HB.Recent progress on liver kinase B1 (LKB1):expression,regulation,downstream signaling and cancer suppressive function.Int J Mol Sci,2014,15:16698-16718. 10 Rana S,Blowers EC,Natarajan A.Small molecule adenosine 5′-monophosphate activated protein kinase (AMPK) modulators and human disease.J Med Chem,2015,58:2-29. 11 Shackelford DB,Shaw RJ.The LKB1-AMPK pathway:metabolism and growth control intumoursuppression.Nat Rev Cancer,2009,9:563-575. 12 Kottakis F,Nicolay BN,Roumane A,et al.LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.Nature,2016,539:390-395. 13 Qanungo S,Haldar S,Basu A.Restoration of silenced Peutz-Jeghers syndrome gene,LKB1 induces apoptosis in pancreatic carcinoma cells.Neoplasia,2003,5:367-374. 14 Zhang W,Wang Q,Wu Y,et al.Endothelial cell-specific liver kinase B1 deletion causes endothelial dysfunction and hypertension in mice in vivo.Circulation,2014,129:1428-1439. 15 Scott KD,Nath-Sain S,Agnew MD,et al.LKB1 catalytically deficient mutants enchance cyclin D1 expression.Cancer Res,2007,67:5622-5627. 16 Lee SM,Choi JE,Na YK,et al.Genetic and epigenetic altera Tions of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung Cancers.Lung Cancer,2013,81:530-538. 17 Petursson F,Husa M,June R,et al.Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes.Arthritis Res Ther,2013,15:77. 18 Wang YZ,Chen Y,Yu L.The Discovery and Research of Autophagy.Chin J Biochem Mol Biol,2018,34:229-239. 19 张志强,王梓瑛,王晓舟,等.LKB1 对胰腺癌细胞迁移侵袭及上皮间质转化的影响及机制研究.实用癌症杂志,2016,31:362-365. 20 Rhodes LV,Tate CR,Hoang VT,et al.Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1. Oncogenesis,2015,4:168. 21 Chen YX,Liu Y,Lou LL,et al.LKB1 inhibits the proliferation and invasion of human lung giant cell cancer cell line through down-regulating the phosphorylation of mTOR and the expression of VEGF and MMP9. Chin J Histochem Cytochem,2017,26:205-211. 22 Gao Y,Xiao Q,Ma H,et al.LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.Proc Natl Acad SCI USA,2010,207:18892-18897. 23 张娜娜,王琼,石敏,等.LKB1基因多态性与2型糖尿病相关性研究.现代生物医学进展,2018,3:504-508. 24 Chin-Hsiao T.Metformin and endometrial cancer risk in Chinese women with type 2 diabetes mellitus in Taiwan.Gynecol Oncol,2015,138:147-153. 25 Li J,Liu J,Li PP,et al.Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.J Exp Clin Cancer Res,2014,33:70. 26 和倩倩,石琨.脂肪因子与子宫内膜癌的研究进展.中华实用诊断与治疗杂志,2014,28:428-430. 27 Gormand A,Berggreen C,Amar L,et al.LKB1 signalling attenuates early events of adipogenesis and responds to adipogenic cues.Journal of molecular endocrinology,2014,53:117-130. 28 Burdakov D,Karnani MM,Gonzalez A.Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control.Physiol Behav,2013,121:117-124. 29 Shirazi RS,Ewert KK,Silva BF,et al.Structural evolution of environmentally responsive cationic liposom e-DNA com plexes with a reducible lipid linker.Langm uir,2012,28:10495-10503. 30 Contreras CM,Akbay EA,Gallardo TD,et al.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.Dis Model Mech,2016,43:181-193. 31 王丽红,郭春燕,瞿全新.LKB1/AMPK/mTOR 信号转导通路在子宫内膜癌发病机制中的研究.中国妇幼保健,2014,29:1933-1936. 32 Cyriac K,Nikolaus S,Cherniack AD,et al.Integrated genomic characterization of endometrial carcinoma.Nature,2014,497:67-73. 33 Li AL,Bai XH.Expression and Clinical Significance of LKB1 in Endometrial Carcinomas.J China Med Univ,2013,42:221-224. 34 CoNN,Iglesias D,Celestino J,et al.Loss of LKB1 in high-grade endometrial carcinoma:LKB1 is a novel transcriptional target of p53. Cancer,2014,12:3457-3468. 35 Peña CG,Nakada Y,Saatcioqlu HD,et al.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.Clin Invest,2015,125:4063-4076. 36 Contreras CM,Gurumurthy S,Haynie JM,et al.Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.Cancer Res,2008,68:759-766.
