Abstract:Objective To investigate the clinical significance of platelets and their related parameters such as platelet to lymphocyte ratio (PLR), platelet to neutrophil ratio (PNR), and platelet to mononuclear ratio (PMR) in peripheral blood of patients with epithelial ovarian tumor before operation. Methods 272 patients who underwent the first operation of ovarian tumor surgery in the First Affiliated Hospital of Harbin Medical University from June 2015 to June 2018 were collected and divided into the benign group and the malignant group according to the pathological type of the tumor. Among them, the benign group included 175 cases, all of which were serous and mucinous cystadenomas, and the malignant group included 97 cases. According to the binary theory, the malignant group was divided into type I and type II group, with 34 cases in type I group (including low-grade ovarian serous carcinoma, low-grade ovarian endometrioid carcinoma, clear cell carcinoma of ovary and mucinous carcinoma) and 63 cases in type II group(including high-grade ovarian serous carcinoma, high-grade ovarian endometrioid carcinoma, undifferentiated ovarian carcinoma, and carcinosarcoma). According to the pathological stages, the malignant group was divided into stage I-II group (52 cases) and stage III-IV group (45 cases). The results of fasting peripheral blood routine results were collected after admission before any drug or surgical treatment was given, and neutrophils, lymphocytes, monocytes, platelets, plateletcrit, mean platelet volume and platelet distribution width were collected from the peripheral blood routine results, and PLR, PNR and PMR were calculated. The above indexes were expressed as mean ± standard deviation, and the t-test of two independent samples was used to analyze the difference between the benign group and the malignant group, the type I group and the type II group, and the stage I-II group and the stage III-IV group. The ROC curve was drawn to evaluate the prediction effect of PLT and PLR on the pathological stage of the malignant group and PNR and PMR on the pathological type of the malignant group. Results Compared with benign and malignant group, neutrophils, monocytes and platelets in malignant group increased, lymphocyte decreased; PLR increased (P<0.01); PNR and PMR decreased while there was no statistical significance. In the pathological stage of malignant group, PLT and PLR were significantly higher in stage III-IV group than in stage I-II group(P<0.05); PLR had a certain predictive effect on malignant stage (AUC=0.62, P=0.03), and the critical point was 192.73; PLT had no statistical significance on the prediction of malignant stage. In the pathological type of malignant group, PNR and PMR were lower in type I group than in type II group, the difference was statistically significant (p<0.05); PNR and PMR had no statistical significance on predicting type I and II group, but the area under curve (AUC) of PNR was 0.58, and the specificity was 73.53% when the critical point was 72.45. Conclusion PLT and PLR in preoperative peripheral blood of patients with ovarian cancer are associated with pathological stage of ovarian cancer. PNR and PMR may be closely related to the pathological types I and II, which may be helpful for the analysis and treatment of ovarian cancer.
汤妍妍, 郭秋艳, 张广美. 上皮性卵巢肿瘤患者术前外周血血小板及相关参数的临床分析[J]. 中国生育健康杂志, 2020, 31(2): 107-111.
TANG Yanyan, GUO Qiuyan, ZHANG Guangmei. Clinical significance of platelets and related parameters in patients with epithelial ovarian tumor before operation. Chinese Journal of Reproductive Health, 2020, 31(2): 107-111.
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