广东省育龄妇女自然流产发生情况及其影响因素分析

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摘要目的探索广东省育龄妇女自然流产的发生情况及其影响因素。方法选取广东省2017年参与国家免费孕前健康检查的20～53岁已婚育龄妇女为研究对象,共计104 300例,妇女平均年龄(27.6±4.5)岁,其中农村户籍81 185例,城市户籍23 115例。采用卡方检验与Logistic回归模型分析孕前高龄、常见生殖道感染、常见性病和TORCH感染等不良风险因素与自然流产的关系。结果共随访104 300例育龄妇女,总妊娠结局104 300例,自然流产2 363例,总自然流产发生率为2.3%,其中城市自然流产发生率为3.9%,农村自然流产的发生率为1.8%。高龄(OR=2.76,95% CI:2.50～3.06)、不良妊娠史(OR=1.77,95% CI:1.61～1.94)、不良饮食习惯(OR=1.43,95% CI:1.16～1.94)、不良生活习惯(OR=1.70,95% CI:1.24～2.32)、高血压(OR=1.63,95% CI:1.25～22.11),常见生殖道感染(OR=2.44, 95% CI:2.20～2.70)均为自然流产的危险因素。未发现孕前感染淋病、沙眼支原体、梅毒和TORCH与自然流产有显著关联。结论广东省参与孕前优生项目育龄妇女的自然流产率处于较低水平,孕前检查与干预有利于减少自然流产的发生,应加强孕前优生指导。

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	陈水莲
	梁志江
	黄冠豪
	李兵
	赵庆国

关键词 ：自然流产, 孕前优生, 影响因素

Abstract：Objective To explore the prevalence rate of spontaneous abortion and its risk factors in Guangdong Province. Methods In 2017, women aged from 20 to 53 years(104 300,city:23 115, Countryside:81 185)who participated in the national pre-pregnancy health in Guangdong province were included in the study. Among 104 300 included women (average age:[27.6±4.5] years), 23 115 were from city and 81 185 from countryside. Chi-square test and logistic regression model were used to explore the relationship between spontaneous abortion and pre-pregnancy adverse factors including advanced age, reproductive tract infections, venereal disease, TORCH infection, etc. Results Among 104 300 pregnant women, 2 363 had spontaneous abortions, resulting in an overall rate of spontaneous abortion of 2.3% (2 363/104 300). The spontaneous abortion rate was 3.9% (898/23 115) for women from city, and 1.8% (1 465/81 185) for those from countryside. Women with advanced age (OR=2.76, 95% CI:2.50-3.06), adverse pregnancy history (OR=1.77, 95% CI:1.61-1.94) , unhealthy dietary habits (OR=1.43, 95% CI:1.16-1.94), unhealthy lifestyle (OR=1.70, 95% CI:1.24-2.32), hypertension (OR=1.63, 95% CI:1.25-22.11), and common reproductive tract infection (OR=2.44, 95% CI:2.20-2.70) had higher risk of spontaneous abortion. We did not found significant association of spontaneous abortion with pre-pregnancy gonorrhea, trachomatis, syphilis, or TORCH infection. Conclusion The spontaneous abortion rate for women participated in the national pre-pregnancy health in Guangdong province is at a low level. Pre-pregnancy examination and intervention are benefit for reducing the occurrence of spontaneous abortion. There is a need to strengthen pre-pregnancy guidance.

Key words： spontaneous abortion pre-pregnancy eugenics influence factors

收稿日期: 2019-01-08

通讯作者: 赵庆国(zqgfrost@126.com)

引用本文:

陈水莲, 梁志江, 黄冠豪, 李兵, 赵庆国. 广东省育龄妇女自然流产发生情况及其影响因素分析[J]. 中国生育健康杂志, 2020, 31(2): 119-122.
CHEN Shuilian, LIANG Zhijiang, HUANG Guanhao, LI Bing, ZHAO Qingguo. Epidemiology of spontaneous abortion and its risk factors in Guangdong province. Chinese Journal of Reproductive Health, 2020, 31(2): 119-122.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I2/119

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