1 Bray F,Ferlay J,Soerjomataram I,et al.Global Cancer Statistics 2018:GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.CA Cancer J Clin,2018;68:394-424. 2 Shah MM,Landen CN.Ovarian cancer stem cells:are they real and why are they important?.Gynecol Oncol,2014,132:483-489. 3 Bapat SA,Mali AM,Koppikar CB,et al.Stem and Progenitor-Like Cells Contribute to the Aggressive Behavior of Human Epithelial Ovarian Cancer.Cancer Res,2005,65:3025-3029. 4 Shoichiro T,Nakayama KI.To wake up cancer stem cells,or to let them sleep,that is the question.Cancer Sci,2016,107:875-881. 5 Wang X,Li X,Fu X,et al.Eliminating Ovarian Cancer Stem Cells:A Potential Therapeutic Target for Ovarian Cancer Chemoresistance.Curr Protein Pept Sci,2015,16:270-278. 6 Surowiak P,Materna V,Kaplenko I,et al.ABCC2 (MRP2,cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome.Clin Cancer Res,2006,1:7149-7158. 7 Eyre R,Harvey I,Stemke-Hale K,et al.Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population.Tumour Biol,2014,35:9879-9892. 8 Du YR,Chen Y,Gao Y,et al.Effects and mechanisms of anti-CD44 monoclonal antibody A3D8 on proliferation and apoptosis of sphere-forming cells with stemness from human ovarian cancer.Int J Gynecol Cancer,2013,23:1367-1375. 9 Bourguignon L,Peyrollier K,Xia WE.Hyaluronan-CD44 interaction activates stem cell marker Nanog,Stat-3-mediated MDR1 gene expression,and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.J Biol Chem,2008,283:17635. 10 Conic I,Stanojevic Z,Jankovic VL,et al.Epithelial ovarian cancer with CD117 phenotype is highly aggressive and resistant to chemotherapy.J Obstet Gynaecol Res,2015,41:1630-1637. 11 Chen J,Wang J,Zhang Y,et al.Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three-dimensional cell culture.J Biosci Bioeng,2014,118:214-222. 12 Luo L,Zeng J,Liang B,et al.Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome.Exp Mol Pathol,2011,91:596-602. 13 Liu BL,Liu SJ,Baskys A,et al.Platinum sensitivity and CD133 expression as risk and prognostic predictors of central nervous system metastases in patients with epithelial ovarian cancer.BMC Cancer,2014,14:829. 14 Lan C,Mooney C,Lim J,et al.Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells.Cancer Biol Ther,2013,14:184-192. 15 Spizzo G,Went P,Dirnhofer S,et al.Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer.Gynecol Oncol,2006,103:483-488. 16 Tayama S,Motohara T,Narantuya D,et al.The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer.Oncotarget,2017,8:44312-44325. 17 Sharrow AC,Perkins B,Collector MI,et al.Characterization of aldehyde dehydrogenase 1 high ovarian cancer cells:Towards targeted stem cell therapy.Gynecol Oncol,2016,142:341-348. 18 Li Y,Chen T,Zhu J,et al.High ALDH activity defines ovarian cancer stem-like cells with enhanced invasiveness and EMT progress which are responsible for tumor invasion.Biochem Biophys Res Commun,2018,495:1081-1088. 19 Mizuno T,Suzuki N,Makino H,et al.Cancer stem-like cells of ovarian clear cell carcinoma are enriched in the ALDH-high population associated with an accelerated scavenging system in reactive oxygen species.Gynecol Oncol,2015,137:299-305. 20 Januchowski R,Wojtowicz K,Sterzyńska K,et al.Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.Int J Biochem Cell Biol,2016,78:248-259. 21 Cheng W,Liu T,Wan X,et al.MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells.FEBS J,2012,279:2047-2059. 22 Park YT,Jeong JY,Lee MJ,et al.MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance.J Ovarian Res,2013,6:1-11. 23 Grosse-Gehling P,Fargeas CA,Dittfeld C,et al.CD133 as a biomarker for putative cancer stem cells in solid tumours:limitations,problems and challenges.J Pathol,2013,229:355-378. 24 Naujokat C.Monoclonal antibodies against human cancer stem cells.Immunotherapy,2014,6:290-308. 25 He M,Wang D,Zou D,et al.Re-purposing of curcumin as an anti-metastatic agent for the treatment of epithelial ovarian cancer:in vitro model using cancer stem cell enriched ovarian cancer spheroids.Oncotarget,2016,7:86374.