1 Liu J,Liu X,Ma W,et al.Anticancer activity of cucurbitacin-A in ovarian cancer cell line SKOV3 involves cell cycle arrest,apoptosis and inhibition of mTOR/PI3K/Akt signaling pathway.J Buon,2018,23:124-128. 2 Zhang T,Xu J,Deng S,et al.Core signaling pathways in ovarian cancer stem cell revealed by integrative analysis of multi-marker genomics data.PLoS One,2018,13:e0196351. 3 Miao B,Skidan I,Yang J,et al.Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.Autophagy,2010,107:20126-20131. 4 Gasparri ML,Besharat ZM,Farooqi AA,et al.MiRNAs and their interplay with PI3K/AKT/mTOR pathway in ovarian cancer cells:a potential role in platinum resistance.J Cancer Res Clin Oncol,2018,144:2313-2318. 5 Network TCGA.Integrated genomic analyses of ovarian carcinoma.Nature,2011,474:609-615. 6 Liby TA,Spyropoulos P,Buff Lindner H,et al.Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells.Int J Cancer,2012,130:532-543. 7 Li H,Zeng J,Shen K.PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer.Arch Gynecol Obstet,2014,290:1067-1078. 8 Zhang D,Xia H,Zhang W,et al.The anti-ovarian cancer activity by WYE-132,a mTORC1/2 dual inhibitor.Tumour Biol,2016,37:1327-1336. 9 Tran TN,Brettingham-Moore K,Duong CP,et al.Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.J Surg Oncol,2013,108:113-120. 10 Konstantinopoulos PA,Spentzos D,Karlan BY,et al.Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer.J Clin Oncol,2010,28:3555-3561. 11 Mukhopadhyay A,Elattar A,Cerbinskaite A,et al.Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.Cli n Cancer Res,2010,16:2344-2351. 12 Fruman DA,Rommel C.PI3K and cancer:lessons,challenges and opportunities.Nat Rev Drug Discov,2014,13:140-156. 13 Dobbin ZC,Landen CN.The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer.Int J Mol Sci,2013,14:8213-8227. 14 Wu MF,Yang J,Xiang T,et al.miR-21 targets Fas ligand-mediated apoptosis in breast cancer cell line MCF-7.J Huazhong Univ Sci Technolog Med Sci,2014,34:190-194. 15 Wang M,Su P.The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis:An update.Syst Biol Reprod Med,2018,64:93-102. 16 Yamada A,Arakaki R,Saito M,et al.Dual Role ofFas/FasL-Mediated Signal in Peripheral Immune Tolerance.Front Immunol,2017,8:403. 17 刘培淑,董瑞英,李爱华.Fas/FasL系统与卵巢肿瘤的免疫逃逸的研究.中华肿瘤防治杂志,2003,10:621-623. 18 李娜,吴月明,周立霞.非小细胞肺癌组织中VEGF与PEDF的表达及其临床意义.江苏医药,2017,43:1228-1231. 19 Yang J,Yan J,Liu B.Targeting VEGF/VEGFR to Modulate Antitumor Immunity.Front Immunol,2018,9:978. 20 Erolu A,Ersz C,Karasoy D,et al.Vascular endothelial growth factor (VEGF)-C,VEGF-D,VEGFR-3 and D2-40 expressions in primary breast cancer:Association with lymph node metastasis.Adv Clin Exp Med,2017,26:245-249. 21 Pihapaul SA,Wheler JJ,Fu S,et al.Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus.Oncotarget,2014,5:1846-1855. 22 宁尼亚,刘松凡.VEGF与卵巢癌的研究进展.中国当代医药,2014,186-188. 23 Roskoski R Jr.Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas.Pharmacol Res,2017,120:116-132. 24 Chuderland D,Ben-Ami I,Bar-Joseph H,et al.Role of pigment epithelium-derived factor in the reproductive system.Reproduction,2014,148:R53. 25 Xie TY,Zhang CL,Chen XY.VEGF,HIF-1α and PEDF expression in the retina of streptozotocin-induced diabetics rats treated with ozone.Guoji Yanke Zazhi,2016,16:195-200. 26 Rivera-Pérez J,Monter-Vera MDR,Barrientos-Alvarado C,Toscano-Garibay JD,Cuesta-Mejías T,Flores-Estrada J.Evaluation of VEGF and PEDF in prostate cancer:A preliminary study in serum and biopsies.Oncol Lett,2018,15:1072-1078. 27 Harries RL,Owen S,Ruge F,et al.Impact of pigment epithelium-derived factor on colorectal cancer in vitro and in vivo.Oncotarget,2018,9:19192-19202. 28 Chuderland D,Ben-Ami I,Bar-Joseph H,et al.Role of pigment epithelium-derived factor in the reproductive system.Reproduction,2014,148:R53-61.