上皮-间质转化(EMT)在上皮性卵巢癌的作用

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摘要上皮-间质转化(EMT)将良性肿瘤转化为具有侵袭性和转移性肿瘤的潜在作用而受到广泛关注,它是一个复杂及可逆的过程,在此过程中细胞表型、功能及大量分子表达发生变化。EMT是正常胚胎发育所必需的生理过程。然而,在病理情况下,这种转变可能是变态的,且有文献报道,EMT在上皮性肿瘤的发生、侵袭及转移过程起关键作用。它涉及多个信号通路和复杂的分子机制,本文对EMT多个信号通路及相关转录因子(ZEB1、KLF4)与上皮性卵巢癌的发生、发展进行综述,为上皮性卵巢癌早期诊断提供新的研究思路。

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	袁少艳
	何秀萍

关键词 ：上皮性卵巢癌(EOC), 上皮-间质转化(EMT), 信号通路

收稿日期: 2018-10-08

通讯作者: 何秀萍(Xiuping_ng_he@live.cn)

引用本文:

袁少艳, 何秀萍. 上皮-间质转化(EMT)在上皮性卵巢癌的作用[J]. 中国生育健康杂志, 2020, 31(6): 588-589.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I6/588

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