Study on the association between physical activity and plasma folate concentration among women of childbearing age
CHEN Jingsong, ZHANG Le, JI Ying, LIU Jufen
Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University; Beijing 100191, China
Abstract:Objective To investigate the effect of physical activity on blood folate levels among non-pregnant women of childbearing age.Methods The study was based on the "Survey on nutritional status among women of childbearing age in different regions of China" which was conducted in 9 provinces/autonomous regions in 2004-2005 by the former Ministry of Health of China in cooperation with World Health Organization. A total of 3 660 women were investigated from December 1 to December 31, 2004 (winter and spring) and from September 1 to September 30, 2005 (summer and Autumn) in the original study. The basic information was collected through questionnaire and physical examination. Physical activity was investigated by the International Physical Activity Questionnaire (IPAQ) short form. Plasma folate concentration was determined by microbiological method and plasma folate <10.5 nmol/L was defined as plasma folate deficiency. Logistic regression was used to analyze the correlation between physical activity and plasma folate concentration among women of childbearing age.Results Finally 3 095 non-pregnant women of childbearing age were included in current study, with a mean age of (25.8±3.5) years, predominantly Han Ethnicity (67.4%), majority of them with junior high school or less (46.8%). The mean plasma folate concentration was 18.02 nmol/L and plasma folate deficiency rate of 29.8%. After controlling for dietary folate intake, BMI, season and other factors, plasma folate deficiency was more likely to occur with physical activity ≤3 times/Monthly within the past six months (OR=2.27, 95% CI=1.58-3.25); moderate physical activity level was a protective factor for plasma folate deficiency (OR=0.52, 95% CI=0.38-0.71); medium and high levels of physical activity were protective factors for lower dietary folate (medium:OR=0.77, 95% CI=0.60-0.99; high:OR=0.67, 95% CI=0.53-0.84).Conclusion Insufficient exercise within six months might be associated with folate deficiency among non-pregnant women of childbearing age, and moderate physical activity level might be associated with folate deficiency. Increasing exercise frequency and maintaining moderate activity level with the increased dietary folate intake would be recommended to maintain appropriate folate among non-pregnant women of childbearing age.
陈靖松, 张乐, 纪颖, 刘菊芬. 育龄妇女身体活动与血浆叶酸水平关系的研究[J]. 中国生育健康杂志, 2021, 32(6): 501-507.
CHEN Jingsong, ZHANG Le, JI Ying, LIU Jufen. Study on the association between physical activity and plasma folate concentration among women of childbearing age. Chinese Journal of Reproductive Health, 2021, 32(6): 501-507.
1 Greene ND,Copp AJ.Neural tube defects.Annu Rev Neurosci,2014,37:221-242. 2 Berry RJ,Li Z,Erickson JD,et al.Prevention of neural-tube defects with folic acid in China.China-U.S.Collaborative Project for Neural Tube Defect Prevention.N Engl J Med,1999,341:1485-1490. 3 Hao L,Yang QH,Li Z,et al.Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial.Am J Clin Nutr,2008,88:448-457. 4 Bull FC,Al-Ansari SS,Biddle S,et al.World Health Organization 2020 guidelines on physical activity and sedentary behaviour.Br J Sports Med,2020,54:1451-1462. 5 Kim YN,Hwang JH,Cho YO.The effects of exercise training and acute exercise duration on plasma folate and vitamin B12. Nutr Res Pract,2016,10:161-166. 6 张龙,王新刚,范芳芳,等.北京社区人群血浆叶酸水平及其影响因素的相关性研究.环境与健康杂志,2016,33:972-976. 7 Baart AM,Balvers MGJ,de Vries JHM,et al.Relationship between intake and plasma concentrations of vitamin B12 and folate in 873 adults with a physically active lifestyle:a cross-sectional study.J Hum Nutr Diet,2021,34:324-333. 8 Jia X,Ren M,Zhang Y et al.Association between tea drinking and plasma folate concentration among women aged 18-30 years in China.Public Health Nutr,2020,15:1-8. 9 杨月欣.中国食物成分表2004.北京:北京大学医学出版社.2005. 10 陈朴,潘柏申.血清叶酸和红细胞叶酸检测的临床应用.检验医学,2016,31:232-236. 11 樊萌语,吕筠,何平平.国际体力活动问卷中体力活动水平的计算方法.中华流行病学杂志,2014,35:961-964. 12 Zhao Y,Hao L,Zhang L,et al.Plasma folate status and dietary folate intake among Chinese women of childbearing age.Matern Child Nutr,2009,5:104-116. 13 De BE,Gulbis B,Cotton F.Serum and red blood cell folate testing for folate deficiency:new features? Eur J Haematol,2014,92:354 -359. 14 郝玲,田熠华,章斐然,等.我国部分地区成年人血浆叶酸的地区和季节差异比较.中华预防医学杂志,2002,36:308-310. 15 孙晓岩,陈博,袁细妹,等.东莞市453例育龄妇女血液叶酸水平检测结果分析.中国实用医刊,2018,45:97-99. 16 张铃,韩耀伟.滨海新区塘沽育龄夫妇叶酸水平回顾性调查分析.中国城乡企业卫生,2020,35:73-74. 17 靳荣荣,曲翌敏,李娟娟,等.北京市郊区育龄妇女叶酸服用现状调查.中华流行病学杂志,2017,38:1347-1351. 18 Herrmann M,Schorr H,Obeid R,et al.Homocysteine increases during endurance exercise.Clin Chem Lab Med,2003,41:1518-1524. 19 Bailey DM,Davies B,Baker J.Training in hypoxia:modulation of metabolic and cardiovascular risk factors in men.Med Sci Sports Exerc,2000,32:1058-1066. 20 Deminice R,Rosa FT,Franco GS,et al.Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.Eur J Nutr,2014,53:1355-1361. 21 Alomari MA,Khabour OF,Gharaibeh MY,et al.Effect of physical activity on levels of homocysteine,folate,and vitamin B12 in the elderly.Phys Sportsmed,2016,44:68-73. 22 Maroto-Sánchez B,Lopez-Torres O,Palacios G,et al.What do we know about homocysteine and exercise? A review from the literature.Clin Chem Lab Med,2016,54:1561-1577. 23 Neuman JC,Albright KA,Schalinske KL.Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model.Nutr Res,2013,33:487-493. 24 Joubert LM,Manore MM.The role of physical activity level and B-vitamin status on blood homocysteine levels.Med Sci Sports Exerc,2008,40:1923-1931. 25 Woolf K,Hahn NL,Christensen MM,et al.Nutrition Assessment of B-Vitamins in Highly Active and Sedentary Women.Nutrients,2017,9:329. 26 Woolf K,Manore MM.B-vitamins and exercise:does exercise alter requirements? Int J Sport Nutr Exerc Metab,2006,16:453-484. 27 Desai A,Sequeira JM,Quadros EV.The metabolic basis for developmental disorders due to defective folate transport.Biochimie,2016,126:31-42. 28 Child DF,Hudson PR,Jones H,et al.The effect of oral folic acid on glutathione,glycaemia and lipids in Type 2 diabetes.Diabetes Nutr Metab,2004,17:95-102. 29 Shahriarpour Z,Nasrabadi B,Hejri-Zarifi S,et al.Oxidative balance score and risk of osteoporosis among postmenopausal Iranian women.Arch Osteoporos,2021,25:16-43. 30 Mora S,Lee IM,Buring JE,et al.Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women.JAMA,2006,295:1412-1419. 31 Asbaghi O,Ghanavati M,Ashtary-Larky D,et al.Effects of Folic Acid Supplementation on Oxidative Stress Markers:A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Antioxidants (Basel).2021,10:871. 32 Bjørklund G,Peana M,Dadar M,et al.The role of B vitamins in stroke prevention.Crit Rev Food Sci Nutr,2021,16:1-14. 33 Kaye AD,Jeha GM,Pham AD,et al.Folic Acid Supplementation in Patients with Elevated Homocysteine Levels.Adv Ther,2020,37:4149-4164.