宫颈病变中不同基因位点的甲基化修饰

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摘要在国内,宫颈癌每年的发病率居女性恶性肿瘤的第二位,并且宫颈癌也是女性癌症死亡的主要原因。除传统观念认为的高危型HPV持续感染、多个性伴侣、初次性行为早等危险因素外,表观遗传学的改变,如DNA甲基化在宫颈病变中被发现,并随着病变程度增加有相应的增加等,均被认为是导致宫颈癌发生、发展的因素。因此,对相关基因甲基化的分析,可作为预测和评估宫颈癌癌前病变的方法。而不同基因,如PAX1、SOX1、DAPK1、ZNF582等基因的来源、基因表达及其对宫颈病变影响程度均有所不同。本研究就现阶段多种在宫颈病变存在的不同甲基化修饰基因做一综述。

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	于小雨
	刘玉玲

关键词 ：宫颈癌, 甲基化, 宫颈上皮内瘤变, 抑癌基因, 人乳头瘤病毒

收稿日期: 2019-09-12

引用本文:

于小雨, 刘玉玲. 宫颈病变中不同基因位点的甲基化修饰[J]. 中国生育健康杂志, 2021, 32(6): 593-594.

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http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2021/V32/I6/593

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