固醇调节元件结合蛋白1与多囊卵巢综合征关系的研究进展

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摘要多囊卵巢综合征(PCOS)病因复杂,临床表现多样,常表现有糖脂代谢异常、胰岛素抵抗(IR)、高雄激素血症(HA)以及其他典型症状。多项研究表明,固醇调节元件结合蛋白1(SREBP1)的表达与PCOS关系密切,与亚洲PCOS遗传易感性显著相关。SREBP1作为调控血脂和糖代谢的关键转录因子,被发现与IR相关,可被认为是引起IR的因素之一。雄激素能够参与调节与SREBP(SREBP1和SREBP2)有关的水解基因并使SREBP1表达增加,因此,SREBP1与PCOS有千丝万缕的关系。实验表明,运用药物或电针能够调控SREBP1进而调节血脂水平和IR症状,这为PCOS的治疗提供了新的思路。

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	罗越
	彭艳
	杨新鸣
	姚美玉

关键词 ：多囊卵巢综合征(PCOS), 固醇调节元件结合蛋白1(SREBP1), 糖脂代谢, 雄激素, 胰岛素抵抗(IR)

收稿日期: 2020-12-29

ZTFLH:

R17

基金资助:黑龙江中医药大学研究生创新科研项目(2019yjscx025);国家自然科学基金青年基金(81704114);国家区域诊疗中心黑龙江省名中医传承工作室建设项目(黑中科教便函〔2019〕2 号)

通讯作者: 姚美玉(yaomeiyupxx@163.com)

引用本文:

罗越, 彭艳, 杨新鸣, 姚美玉. 固醇调节元件结合蛋白1与多囊卵巢综合征关系的研究进展[J]. 中国生育健康杂志, 2022, 33(4): 397-400.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2022/V33/I4/397

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