Abstract：Objective To study the level of dietary inflammation index of women in Beijing during pregnancy, and to explore the correlation between dietary inflammation index and pregnancy outcome. Methods From April 2018 to April 2019, pregnant women who underwent prenatal examination in a Maternal and Child Health Hospital in Beijing were selected. Questionnaire surveys were conducted to collect the basic information, birth history, dietary information, the serum inflammatory factors (CRP and TNF) were detected by enzyme-linked immunosorbent assay- α、 IL-1 β、 IL-4, IL-6 and IL-10), and the dietary inflammation index during pregnancy was calculated. Multiple linear regression was used to analyze the relationship between dietary inflammation index and pregnancy outcomes such as pregnancy weight gain, neonatal birth weight, preterm birth and fetal distress. Results the average dietary inflammatory index of 113 pregnant women during pregnancy was normally distributed. Compared with those with lower dietary inflammatory index, the serum CRP and TNF of pregnant women with higher dietary inflammatory index- α And IL-6 concentrations increased significantly. The level of dietary inflammatory index during pregnancy will significantly affect the weight gain during pregnancy (P=0.009), and the increase of dietary inflammatory index during pregnancy and early pregnancy will lead to insufficient weight gain in early pregnancy (P=0.031); The increase of dietary inflammatory index in the third trimester of pregnancy significantly increased the risk of low birth weight (P=0.020) and preterm birth (P=0.024); Increased mean dietary inflammatory index during pregnancy increased the risk of fetal distress (P=0.048). Conclusion Dietary inflammatory index during pregnancy affects weight gain during pregnancy and increases the risks of neonatal birth weight, premature delivery and fetal distress. It is suggested that pregnant women should pay attention to scientific diet during pregnancy and reduce the risk of adverse pregnancy outcome caused by dietary inflammatory factors.
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