Abstract:Objective To investigate the association between intrauterine exposure to gestational diabetes mellitus (GDM) and anthropometric growth of infants from birth to 8 months and provide evidence for the impacts of GDM on fetal and infants growth. Methods The subjects were pregnant women and their offspring from a longitudinal cohort. Pregnant women were followed up from recruitment (gestational age less than 20 weeks) until their offspring were 8 months. Information on pregnancy characteristics was collected through questionnaire, and that on delivery and infant growth was extracted from the electronic information system of Beijing Haidian Maternal and Child Health Hospital. The linear mixed model was used to analyze the association between GDM and anthropometric growth z-scores from birth to 8 months. Linear regression models were used to analyze the association between GDM and anthropometric growth indicators at different stages of follow-up. Results A total of 845 mother-infant dyads were included in this study. The number of mother-infant dyads completed the follow-up at 42 days, 3 months, 5 months and 8 months were 475, 304, 159 and 131, respectively. Compared with the non-GDM group, the weight for age Z score (WAZ, β=0.16, 95%CI 0.08-0.36), and length for age Z score (LAZ, β=0.16, 95%CI 0.02-0.30) at birth, LAZ at 42 days after birth (β=0.24, 95%CI 0.03-0.45) were higher among infants with intrauterine exposure to GDM. Conclusion GDM was associated with higher WAZ and LAZ at birth and higher LAZ at 42 days after birth.
谭畅, 李梦诗, 贾晓倩, 任梦圆, 张乐, 李智文, 闫琦, 刘晓红, 张敬旭. 宫内暴露于妊娠期糖尿病与婴儿0~8个月体格生长的关联[J]. 中国生育健康杂志, 2023, 34(1): 6-11.
TAN Chang, LI Mengshi, JIA Xiaoqian, REN Mengyuan, ZHANG Le, LI Zhiwen, YAN Qi, LIU Xiaohong, ZHANG Jingxu. The association between intrauterine exposure to gestational diabetes mellitus and anthropometric growth of offsprings from birth to 8 months. Chinese Journal of Reproductive Health, 2023, 34(1): 6-11.
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