间苯三酚对冻融胚胎移植患者妊娠结局的影响

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摘要目的探究间苯三酚对冻融胚胎移植(FET)患者妊娠结局的影响。方法对2017年1月—2018年12月在武汉大学人民医院生殖中心行FET治疗的1 305个周期患者的临床资料进行回顾性分析。根据患者胚胎移植后是否行间苯三酚治疗分为对照组(n=860)和间苯三酚治疗组(n=445)。比较两组患者的生化妊娠率、临床妊娠率、胚胎着床率、早期自然流产率以及异位妊娠率。结果间苯三酚治疗组患者早期自然流产率(7.4%)显著低于对照组患者(13.2%,P＜0.05)。两组患者生化妊娠率、临床妊娠率、胚胎着床率及异位妊娠率无显著差异。此外,间苯三酚可以显著降低卵裂球期胚胎移植患者的早期自然流产率(P＜0.05)。对移植囊胚的患者,观察组与对照组妊娠结局无显著差异。结论间苯三酚应用于FET周期可以改善患者妊娠结局,能显著降低患者早期自然流产率。

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	尚叶
	李赛姣
	杨菁

关键词 ：间苯三酚, 冻融胚胎移植, 妊娠结局

收稿日期: 2021-09-28

ZTFLH:	R71
	R17

基金资助:国家自然科学基金(81771618);国家自然科学青年基金(81701412);湖北省卫生健康科研基金项目(WJ2021M158);湖北省自然科学基金(2018CFB491);中国国家留学基金(CSC NO.201806275007);默克雪兰诺生殖医学基金(MerckSerono_CREATE-2016141)

通讯作者: 杨菁(dryangjing@whu.edu.cn)

引用本文:

尚叶, 李赛姣, 杨菁. 间苯三酚对冻融胚胎移植患者妊娠结局的影响[J]. 中国生育健康杂志, 2023, 34(1): 90-93.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2023/V34/I1/90

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