Abstract：Objective To explore the effect of growth hormone(GH) supplementation on the outcome of the first IVF-ET in elderly patients with diminished ovarian reserve(DOR). Methods This study retrospectively analyzed the data of patients undergoing IVF-ET in the Reproductive Medicine Center of the First Affiliated Hospital of Hainan Medical University from May 2019 to December 2020, and included 236 subjects with advanced age(≥35 years old and ＜40 years old) and DOR. Patients were divided into two groups according to the GH use:118 cases of gonadotropin(Gn) alone were used in the control group, and 118 cases were in the group of both Gn and GH use, respectively. We collected the data of pregnancy outcomes about oocyte retrieval, available embryos, high-quality embryo rate, implantation rate and clinical pregnancy rate. Results There were no significant differences in age, infertility time, body mass index(BMI), antral follicle count(AFC), sex hormone levels, and anti-Müllerian hormone(AMH) values between the two groups(P>0.05). There was no significant difference between the two groups in the total amount and use time of Gn, the level of progesterone(P) plus endometrial thickness on the trigger day, 2PN fertilization rate,average number of transferred embryos and cycle cancellation rate(P>0.05). The number of retrieved oocytes plus available embryos, and high-quality embryos rate in the Gn+GH group were significantly higher than those in the control group(P<0.05). The implantation rate and clinical pregnancy rate in the Gn+GH group were higher than those in the control group, but there was no significant difference between the two groups(P>0.05). Conclusion For elderly patients(≥35 years old and ＜40 years old) with diminished ovarian reserve, GH supplementation during ovulation induction can increase the number of retrieved oocytes plus available embryos, and high-quality embryos rate.
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