Abstract:Objective To investigate the distribution of preconception thyroid stimulating hormone (TSH) in Chinese married women who prepare for pregnancy, and further discuss the factors associated with abnormal preconception TSH levels.Methods Preconception TSH data were drawn from the National Free Pre-pregnancy Checkups (NFPC) during January 2013 and December 2013. Two different reference ranges of TSH were used to judge abnormal preconception TSH level: the reference ranges of TSH test kits and the specific reference range in early pregnancy suggested by America Thyroid Association (ATA) in 2011. In addition, the impact of age, body mass index (BMI), and history of pregnancy on abnormal TSH level before pregnancy were further examined.Results A total of 377 463 women were included in the present study. The median of preconception TSH was 1.73 mU/L. The proportion of smaller than TSH reference range, greater than TSH reference range, smaller than 0.1 mU/L and greater than 2.5 mU/L was 2.5%, 3.3%, 0.9% and 26.6%, respectively. Moreover, age, BMI, and history of pregnancy were all factors associated with the likelihood of an abnormal preconception TSH level.Conclusion The prevalence of abnormal TSH in reproductive-aged women who planned to conceive was different between the range recommended by ATA and the range of the TSH detection kits. Hence, scientific standard TSH reference range specific to women preparing for pregnancy should be established and the screening for thyroid function should be strengthened.
李谦, 杨英, 彭左旗, 马旭. 中国已婚计划怀孕女性孕前TSH水平异常现况及影响因素[J]. 中国生育健康杂志, 2016, 27(3): 201-205.
LI Qian, YANG Ying, PENG Zuoqi, MA Xu. Abnormal TSH levels during the preconceptional period and associated factors in Chinese married women planning to become pregnant. Chinese Journal of Reproductive Health, 2016, 27(3): 201-205.
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