WFIKKN2结合TGF-β家族调控生殖细胞发育的研究进展

曲江雪, 覃清圆, 刘涛, 严杰

中国生育健康杂志 ›› 2022, Vol. 33 ›› Issue (5) : 487-490.

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中国生育健康杂志 ›› 2022, Vol. 33 ›› Issue (5) : 487-490.
综述

WFIKKN2结合TGF-β家族调控生殖细胞发育的研究进展

  • 曲江雪, 覃清圆, 刘涛, 严杰
作者信息 +
文章历史 +

摘要

WFIKKN2属于整合蛋白家族成员,是近年新报道的转化生长因子-β家族成员的胞外结合蛋白,在卵巢、睾丸、大脑和肌肉组织中高表达,与转化生长因子-β家族肌肉生长抑制素、生长分化因子11、转化生长因子-β1、骨形态发生蛋白2和骨形态发生蛋白4等因子特异性结合,但是具体作用尚不清楚。已知转化生长因子-β1、骨形态发生蛋白2和骨形态发生蛋白4参与精子发生,肌肉生长抑制素、转化生长因子-β1、骨形态发生蛋白2和骨形态发生蛋白4参与卵子发生和卵泡发育,推测WFIKKN2可能通过调节转化生长因子-β家族因子的功能正向或者负向调控生殖细胞发生。本文围绕WFIKKN2及其互作因子在调控生殖细胞发生与发育的机制中的最新研究进展进行总结分析。

关键词

WFIKKN2 / TGF-β家族 / 生殖发生 / 生殖发育

引用本文

导出引用
曲江雪, 覃清圆, 刘涛, 严杰. WFIKKN2结合TGF-β家族调控生殖细胞发育的研究进展[J]. 中国生育健康杂志, 2022, 33(5): 487-490
中图分类号: R71   

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基金

国家重点研发计划(2018YFC1004001,2017YFC1002002,2019YFA0801401);国家自然科学基金(81571386,81730038);中国医学科学院医学与健康科技创新工程项目资助(2019-I2M-5-001);首都卫生发展科研专项(2018-2952-4095)

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