目的 了解孕妇孕早期血清维生素A、E水平与子痫前期的关联。方法基于国家卫生健康委医药卫生科技发展研究中心开展的“孕期血清维生素A、E与子痫前期相关性研究”队列进行研究,调查内容包括孕妇基本特征、不同孕期血清维生素A、E水平、是否诊断子痫前期等。参考既往标准,将血清维生素A、E水平划分为缺乏、正常范围、过量三组,计算不同组的子痫前期患病率。应用Logistic回归模型分析孕早期维生素A、E水平与子痫前期发生风险之间的关联。结果本研究共纳入61 555例孕妇,其中子痫前期患病例数为1 426例,患病率为2.3%。在孕早期,子痫前期孕妇的维生素A水平与非子痫前期孕妇差异未见统计学意义,子痫前期孕妇的维生素E水平低于非子痫前期孕妇,差异具有统计学意义。孕早期维生素A缺乏组孕妇子痫前期的风险降低(OR=0.80,95%CI:0.64～0.99),孕早期维生素E缺乏组孕妇子痫前期的风险显著增加(OR=6.54,95%CI:4.98～8.59)。与孕早期维生素A、E均在正常范围的孕妇相比,孕早期维生素A在正常范围、维生素E缺乏的孕妇患子痫前期的风险显著增加(OR=11.61,95%CI:8.65～15.58)。结论孕妇血清维生素A、E水平与子痫前期有关,孕早期维生素E缺乏是子痫前期的危险因素。在孕早期监测维生素A、E水平有助于发现子痫前期高风险人群。
Abstract
Objective To explore the association between serum vitamin A and vitamin E concentrations in first trimester of pregnancy and preeclampsia. Methods The study was based on the cohort about the association between serum vitamins A and E during pregnancy and preeclampsia, which was conducted by Development Center for Medical Science & Technology, National Health Commission of the People′s Republic of China. It included the basic characteristics of pregnant women, serum vitamin A and E concentrations at different stages of pregnancy, and status of preeclampsia. The serum vitamin A and vitamin E concentrations were divided into three groups of deficiency, normal range, and excess. We calculated the prevalence of preeclampsia in different groups. Logistic regression models were used to analyze the association between vitamin A and vitamin E concentrations in first trimester and the risk of preeclampsia. Results A total of 61 555 pregnant women were included in this study, and 1 426 (2.3%) were diagnosed with preeclampsia. In first trimester of pregnancy, no significant difference was found in vitamin A levels between pregnant women with preeclampsia and healthy pregnant controls. Pregnant women with preeclampsia had significantly lower levels of vitamin E in first trimester. The risk of preeclampsia was reduced in pregnant women with vitamin A deficiency (OR=0.80, 95%CI: 0.64-0.99), while the risk of preeclampsia was significantly increased in pregnant women with vitamin E deficiency (OR=6.54, 95%CI: 4.98-8.59). Pregnant women with vitamin A in the normal range and vitamin E deficiency in the first trimester had a significantly increased risk of preeclampsia compared to those with both normal levels of vitamin A and E (OR=11.61, 95%CI:8.65-15.58). Conclusion Serum vitamin A and vitamin E concentrations during pregnancy were associated with preeclampsia. Vitamin E deficiency in first trimester is a risk factor for preeclampsia. Monitoring vitamin A and E concentrations in early pregnancy can help identify high-risk individuals for preeclampsia.
关键词
孕期 /
维生素A /
维生素E /
子痫前期
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Key words
pregnancy /
vitamin A /
vitamin E /
preeclampsia
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中图分类号：
R17
R71
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参考文献
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脚注
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基金
国家重点研发计划(2023YFC2705900)
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