1 Barbara A,Robort M.Present Rnowledge in Nurtrition.荫士安,汪之顼,主译.第8版.北京:现代工业出版社,2004:324-328. 2 Zeisel SH,Da CK.Choline:an essential nutrient for public health.Nutr Rev,2009,67:615-623. 3 Pomytkin NA,Storozheva ZI,Semenova NA,et al.Neuroprotective effect of choline succinate in rats with experimental chronic cerebral ischemia evaluated by cognitive ability tests.Izv Akad Nauk Ser Biol,2007,2:183-187. 4 Tomassoni D,Avola R,Mignini F,et al.Effect of treatment with choline alpho- scerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats.Brain Res,2006,120:183-190. 5 杨永明,卢德勋,甄玉国.胆碱及其应用.饲料博览,2001,3:38-41. 6 刘敏,齐继红,汪之顼.胆碱营养研究进展.环境卫生学杂志,2007,4:56-58. 7 Zeisel SH.Choline:an essential nutrient for humans.Nutrition,2000,16:669-671. 8 Zeisel SH.Choline:critical role during fetal development and dietary require- ments in adults.Annu Rev Nutr,2006,26:229-250. 9 Buchman AL.The addition of choline to parenteral nutrition.Gastroenterology,2009,5:S119-S128. 10 Zeisel SH,Mar MH,Howe JC,et al.Concentrations of choline-containing compounds and betaine in common foods.J Nutr,2003,5:1302-1307. 11 A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate,Other B Vitamins,and Choline and Subcommittee on Upper Reference Levels of Nutrients,Food and Nutrition Board,Institute of Medicine.Dietary Reference Intakes for Thiamin,Riboflavin,Niacin,Vitamin B-6,Vitamin B-12,Pantothenic Acid,Biotin,and Choline.Washington,DC:National Academy Press,1998:390-422. 12 Hollenbeck CB.The importance of being choline.J Am Diet Assoc,2010,110:1162-1165. 13 Zeisel SH.Importance of methyl donors during reproduction.Am J Clin Nutr,2009,2:S673-677. 14 Bjelland I,Tell GS,Vollset SE,et al.Choline in anxiety and depression:the Hordaland Health Study.Am J Clin Nutr,2009,4:056-1060. 15 Chan KC,So KF,Wu EX.Proton magnetic resonance spectroscopy revealed choline reduction in the visual cortex in an experimental model of chronic glaucoma.Exp Eye Res,2009,1:65-70. 16 Mizumori SJY,Patterson TA,Sternberg H,et al.Effects of dietary choline on memory and brainchemistry in aged mice.Neurobiol Aging,1985,1:51-56. 17 Zeisel SH.Nutritional importance of choline for brain development.J Am Coll Nutr,2004,23:621-626. 18 Shaw GM,Carmichael SL,Yang W,et al.Peri-conceptional dietary intake of choline and betaine and neural tube defects in offspring.Am J Epidemiol,2004,160:102-109. 19 Zeisel SH.The fetal origins of memory:the role of dietary choline in optimal brain development.J Pediatr,2006,149:131-136. 20 Velzing-Aarts FV,Holm PI,Fokkema MR,et al.Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy.Am J Clin Nutr,2005,81:1383-1389. 21 Meck WH,Williams CL.Choline supplementation during prenatal development reduces proactive interference in spatial memory.Brain Res Dev Brain Res,1999,10:51-59. 22 Meck WH,Williams CL.Perinatal choline supplementation increases the threshold for chunking in spatial memory.Neuroreport,1997,8:3053-3059. 23 Meck WH,Williams CL.Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats.Neuroreport,1997,8:3045-3051. 24 Meck WH,Williams CL,Cermak JM,et al.Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia.Front Integr Neurosci,2007,1:7. 25 Williams CL,Meck WH,Heyer DD,et al.Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats.Brain Res,1998,794:225-238. 26 Guo-Ross SX,Clark S,Montoya DA,et al.Prenatal choline supplementation protects against postnatal neurotoxicity.J Neurosci,2002,22:RC195. 27 Zeisel SH,Niculescu MD.Perinatal choline influences brain structureand function.Nutr Rev,2006,64:197-203. 28 Zeisel SH.Is maternal diet supplementation beneficial Optimal development of infant depends on mother's diet.Am J Clin Nutr,2009,89:S685-687. 29 Mellott TJ,Kowall NW,Lopez-Coviella I,et al.Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats.Brain Res,2007,1151:1-11. 30 Napoli I,Blusztajn JK,Mellott TJ.Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex.Brain Res,2008,1237:124-135. 31 Chung SY,Moriyama T,Uezu E,et al.Administration of phosphatidylcholine increases brain acetyl-choline concentration and improves memory in mice with dementia.J Nutr,1995,125:1484-1489. 32 Mervis RF.Chronic dietary choline represses age-related loss of dendritic spines in mouse neocortical pyramidal cells.J Neuropathol Exp Neurol,1982,41:363. 33 Yen CL,Mar MH,Zeisel SH.Choline deficiency-induced apoptosis in PC12 cells is associated with diminished membrane phosphatidylcholine and sphingomyelin,accumulation of ceramide and diacylglycerol,and activation of a caspase.FASEB J,1999,13:135-142. 34 Fisher MC,Zeisel SH,Mar MH,et al.Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos.Teratology,2001,64:114-122. 35 Tees RC.The influences of sex,rearing environment,and neonatalcholine dietary supplementation on spatial and nonspatial learningand memory in adult rats.Dev Psychobiol,1999,135:328-342. 36 Holler T,Cermak JM,Blusztajn JK.Dietary choline supplementation in pregnant rats increases hippocampal phospholipase D activity of the offspring.FASEB J,1996,10:1653-1659. 37 Glenn MJ,Kirby ED,Gibson EM,et al.Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats.Brain Res,2008,1237:110-123. 38 Biasi E.Effects of postnatal dietary choline manipulation against MK-801 neurotoxicity in pre- and post-adolescent rats.Brain Res,2010,1362:117-132. 39 Fisher MC,Zeisel SH,Mar MH,et al.Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos.Teratology,2001,64:114-122. 40 Shaw GM,Carmichael SL,Yang W,et al.Periconceptional dietary intake of choline and betaine and neural tube defects in offspring.Am J Epidemiol,2004,160:102-109.