妊娠期细颗粒物(PM2.5)暴露对早产发生的影响

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (736 KB) HTML (34 KB)
输出: BibTeX | EndNote (RIS)

摘要目的使用反距离加权插值法估计PM2.5暴露浓度,探索妊娠期PM2.5暴露对早产发生的影响。方法利用北京市某城区妇幼保健院的病例采集系统,由档案室工作人员、妇幼保健科室医生经过统一培训后,对384例孕产妇和新生儿信息进行收集,完成自设问卷填写,问卷内容包括孕产妇社会人口学信息、婚育史、产前检查情况以及新生儿分娩情况等。其中,病例组有166例,对照组有218例。此外,通过反距离加权插值法对孕妇妊娠期PM2.5暴露进行估计。利用非条件Logistic回归进行分析。结果多因素分析结果显示,妊娠合并症胎膜早破(OR=7.11,95% CI:4.12～12.25)、子痫或子痫前期(OR=10.23,95% CI:3.39～30.88)、孕期增重不足(OR=2.88,95% CI:1.55～5.36)是早产发生的危险因素;孕晚期PM2.5暴露每增加1 μg/m³,早产发生风险增加2%(OR=1.02,95% CI:1.01～1.04)。而产前检查(OR=0.15, 95% CI:0.04～0.58)是早产发生的保护因素。结论妊娠期PM2.5暴露与早产发生有关,特别是孕晚期PM2.5暴露会增加早产发生的风险,孕妇妊娠期应更重视自我防护,避免增加早产发生风险。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	韩慧
	王媛媛
	张敬旭

关键词 ：早产, 细颗粒物(PM2.5), 危险因素

Abstract：Objective To investigate the association between PM2.5 exposure in pregnancy and preterm birth.Methods On the basis of the patients’ data management system of a maternal and child health hospital, data on social-demographic characteristics, marriage and reproductive history, prenatal health care examinations, and birth and delivery, for 166 preterm patients and 218 controls, were collected via a self-designed questionnaire by the trained staffs from the medical records department or the maternity and child care department. PM2.5 exposure during pregnancy was estimated by Inverse Distance Weighted (IDW) interpolation, and unconditional logistic regression was used to adjust for potential confounders.Results In multivariate analysis, every 1 ug/m³ increase of exposure of PM2.5 in the third trimester was associated with a 2% increased risk of preterm birth (OR=1.02, 95% CI:1.01-1.04). Besides, premature rupture of membranes (OR=7.11, 95% CI:4.12-12.25), eclampsia or preeclampsia (OR=10.23, 95% CI:3.39-30.88), and inadequate weight gain during pregnancy (OR=2.88, 95% CI:1.55-5.36) were associated with increased risk of preterm birth, while prenatal health care examination was a protective factor of preterm birth (OR=0.15, 95% CI:0.04-0.58).Conclusion PM2.5 exposure, especially PM2.5 exposure in the third trimester during pregnancy, is associated with increased risk of preterm birth. Pregnant women should reduce the exposure of PM2.5 during pregnancy to minimize the associated risks.

Key words： Preterm birth Fine particulate matter(PM2.5) Risk factors

收稿日期: 2017-03-08

通讯作者: 张敬旭(jxzhang@bjmu.edu.cn)

引用本文:

韩慧,王媛媛,张敬旭. 妊娠期细颗粒物(PM2.5)暴露对早产发生的影响[J]. 中国生育健康杂志, 2017, 28(6): 506-509.
HAN Hui, WANG Yuanyuan, ZHANG Jingxu. The association of fine particulate matter exposure during pregnancy with preterm birth. Chinese Journal of Reproductive Health, 2017, 28(6): 506-509.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2017/V28/I6/506

1 Laurent O,Hu J,Li L,et al.A Statewide Nested Case-Control Study of Preterm Birth and Air Pollution by Source and Composition:California,2001-2008.Environ Health Perspect,2016,124:1479-1486.
2 Arora CP,Kacerovsky M,Zinner B,et al.Disparities and relative risk ratio of preterm birth in six Central and Eastern European centers.Croat Med J,2015,56:119-127.
3 程雁鹏,冯永亮,段小丽,等.孕期大气细颗粒物PM2.5暴露及对早产的影响研究.中华流行病学杂志,2016,37:572-577.
4 Stieb DM,Chen L,Beckerman BS,et al.Associations of Pregnancy Outcomes and PM2.5 in a National Canadian Study.Environ Health Perspect,2016,124:243-249.
5 Pereira G,Bell ML,Belanger K,et al.Fine particulate matter and risk of preterm birth and pre-labor rupture of membranes in Perth,Western Australia 1997-2007:a longitudinal study.Environ Int,2014,73:143-149.
6 Lamichhane DK,Leem JH,Lee JY,et al.A meta-analysis of exposure to particulate matter and adverse birth outcomes.Environ Health Toxicol,2015,30:e2015011.
7 Kim E,Park H,Hong YC,et al.Prenatal exposure to PM(1)(0) and NO(2) and children's neurodevelopment from birth to 24 months of age:mothers and Children's Environmental Health (MOCEH) study.Sci Total Environ,2014,481:439-445.
8 Deng Q,Lu C,Norback D,et al.Early life exposure to ambient air pollution and childhood asthma in China.Environ Res,2015,143:83-92.
9 Lu C,Deng L,Ou C,et al.Preconceptional and perinatal exposure to traffic-related air pollution and eczema in preschool children.J Dermatol Sci,2017,85:85-95.
10 Wu J,Winer AM,Delfino RJ.Exposure assessment of particulate matter air pollution before,during,and after the 2003 Southern California wildfires.Atmos Environ,2006,40:3333-3348.
11 刘晓红,张运平,高素红,等.早产影响因素的多中心病例对照研究.中国妇产科临床杂志,2012,5:345-348.
12 罗红,罗晓琴,王云霞,等.高龄产妇并发妊娠期高血压疾病对围生期结局的影响.中国优生与遗传杂志,2007,6:58-59.
13 Alijahan R,Hazrati S,Mirzarahimi M,et al.Prevalence and risk factors associated with preterm birth in Ardabil,Iran.Iran J Reprod Med,2014,12:47-56.