Abstract：Objective To explore the interrelationship between subclinical hypothyroidism (SCH) and gestational diabetes mellitus (GDM), and analyze the pregnancy outcomes of women with SCH and GDM.Methods Patients were enrolled from Haidian District maternal and Child Health Hospital of Beijing, May 2015 to September 2016. 200 women diagnosed with GDM and SCH as experimental group, 200 GDM women with normal thyroid function as GDM group, and 200 SCH women with normal glucose as SCH group. Indicators including rate of postpartum hemorrhage, fetal distress, preterm birth, intrauterine infection, macrosomia, large for gestational age infants (LGA), small for gestational age infants (SGA), newborn infection, pH for umbilical cord blood, thyroid gland function in 16 ~ 20 weeks [Before oral glucose tolerance test (OGTT)] and 30 ~ 34 weeks (after OGTT) were compared between the three groups.Results Higher prevalence of preterm birth and intrauterine infection were observed in the experimental group, compared with GDM group and SCH group, with statistical significance. A higher proportion of women used insulin in the experimental group than GDM group, the difference was statistically significant. There were no significant difference in neonatal infection, macrosomia and SGA. The thyroid stimulating hormone (TSH) after OGTT was higher than that before OGTT in experimental group, and the difference was statistically significant. There was no significant difference of TSH among group before and after OGTT in SCH.Conclusion Women with GDM and SCH have higher prevalence of preterm birth, intrauterine infection, and higher proportion of using insulin. TSH may increase in the second and third trimester.
杨明芳,陈磊,赵璐,李贝,史峻梅,李悦. 亚临床甲状腺功能减退合并妊娠期糖尿病孕妇的妊娠结局分析[J]. 中国生育健康杂志, 2017, 28(6): 525-528.
YANG Mingfang, CHEN Lei, ZHAO Lu, LI Bei, SHI Junmei, LI Yue. Analysis of the pregnancy outcomes of women with subclinical hypothyroidism and gestational diabetes mellitus. Chinese Journal of Reproductive Health, 2017, 28(6): 525-528.
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