Abstract：Objective To characterize thrombophilia during pregnancy and puerperium.Methods Clinical data were analyzed retrospectively between July 2006 and February 2015 in Peking University People’s Hospital.Results Sixteen cases were diagnosed with thrombophilia in gravidity or parturient according to the results of ultrasound Doppler scanning or computed tomography, including twelve cases of deep vein thrombosis of lower limbs, three cases of pulmonary embolism. Among which one cases was complicated with lower limb thrombosis, and the last one with superior mesenteric venous thrombosis. All cases detected higher value of plasma fibrinogen and D-Dimer. 93.7% (15/16) of the patients had other risk factors in addition to the high coagulation state. Anticoagulant therapy was used for all patients with low molecular weight heparin. Pulmonary artery embolectomy was done emergently in one patient combined with thrombolytic therapy. 10 cases were ended with Cesarean Section, five cases delivered by vagina (among which, three cases of vein thrombosis occurred in pregnancy), and one case was induced abortion in second trimester. Two cases were placed with inferior vena cava filters before pregnancy termination. All newborns were healthy.Conclusion High coagulation state during pregnancy or puerperium is a risk factor of thrombophilia. It is important to recognize other risk factors of thrombophilia, to diagnose and treat the disease properly, in order to improve maternal and fetal outcomes.
张霞, 王雪燕, 刘国莉. 妊娠期及产褥期16例易栓症的诊治分析[J]. 中国生育健康杂志, 2016, 27(1): 28-32.
ZHANG Xia, WANG Xueyan, LIU Guoli. Department of Obstetrics,Peking University People's Hospital, Beijing 100044, China. Diagnosis and treatment of thrombophilia during pregnancy or puerperium: A review of 16 cases. Chinese Journal of Reproductive Health, 2016, 27(1): 28-32.
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