母血、脐血及胎盘中内脂素水平与巨大儿的相关性

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摘要目的探讨母血、脐血及胎盘中内脂素水平与巨大儿发生的关系。方法收集本院分娩的巨大儿(巨大儿组)产妇40例,及正常体重儿(对照组)40例。应用酶联免疫吸附法(ELISA)、免疫组织化学方法测定母血、脐血及胎盘中内脂素水平,分析母血内脂素水平与脐血内脂素水平、出生体重、体重指数、胎盘重量的相关性。结果巨大儿组母血中、脐血中内脂素水平分别为(42.66±5.29)g/L和(43.36±5.25)μg/L,明显高于对照组[(37.30±4.98)μg/L和(39.86±4.27)μg/L],差异均有统计学意义。巨大儿组胎盘中内脂素阳性率(70.0%)明显高于对照组(42.5%),差异有统计学意义。脐血内脂素水平与新生儿出生体重、新生儿BMI、胎盘重量均正相关(r=0.552、0.493、0.501),与母血内脂素水平无关(r=0.330)。母血内脂素水平与新生儿体重及新生儿BMI正相关(r=0.536、0.588)。结论胎盘中内脂素水平的升高可能与巨大儿的发生有关,母血中内脂素水平的变化有可能作为监测指标应用于临床。

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	王晶
	东星
	张学军
	尚丽新

关键词 ：内脂素, 巨大儿, 体重指数, 酶联免疫吸附法, 免疫组织化学方法

Abstract：Objective To investigate the relationship of visfatin levels in maternal serum, cord serum and placenta with fetal macrosomia. Methods 40 high birthweight infants (macrosomia group) and 40 normal birthweight infants (control group) were enrolled in this study. ELISA and immunohistochemistry were used to determine the levels of visfatin in maternal serum, cord serum, and placenta. The correlations of maternal serum visfatin with cord serum, birth weight, body mass index (BMI), and placenta weight were analyzed.Results Visfatin levels in maternal serum and in cord serum were both higher in the macrosomia group than in the control group (Ps<0.05). Visfatin levels in placenta were significantly higher in the macrosomia group than in the control group (P<0.05). Visfatin levels in cord blood showed a positive relationship with birthweight, newborn BMI, and placenta weight (r= 0.552, 0.493, and 0.501, respectively; Ps<0.05), but no relationship with visfatin levels in maternal serum was observed (r=0.330, P<0.05). In addition, visfatin levels in maternal serum were positively correlated with newborn birthweight and BMI (r=0.536 and 0.588, respectively; Ps<0.05).Conclusion A rise of visfatin levels in placenta may be related to the occurrence of fetal macrosomia. The change of visfatin in maternal serum could be used as a monitoring maker for clinical study.

Key words： Visfatin Macrosomia Birth weight Body mass index

收稿日期: 2016-01-15

通讯作者: 尚丽新(13141307059@163.com)

引用本文:

王晶, 东星, 张学军, 尚丽新. 母血、脐血及胎盘中内脂素水平与巨大儿的相关性[J]. 中国生育健康杂志, 2016, 27(4): 328-330.
WANG Jing, DONG Xing, ZHANG Xuejun, SHANG Lixin. The relationship of visfatin levels in maternal, cord serum, and placenta with fetal macrosomia. Chinese Journal of Reproductive Health, 2016, 27(4): 328-330.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2016/V27/I4/328

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