Abstract:Objective The indication and positive rate of karyotype of amniocentesis in our hospital were analyzed, and how to improve the accuracy rate of prenatal screening and prenatal diagnosis was discussed.Methods Analysis of prenatal diagnosis and detection rate of fetal chromosome karyotype analysis in 270 cases of amniocentesis in our hospital.Results In the 270 cases of amniocentesis, the most common three puncture indications were serological triple screening(36.3%), high risk of NIPT (28.2%) and pathological ultrasonography findings (18.5%). The positive detection rate from high to low is:high risk of NIPT (61.8%), parental translocation or marker chromosome carriage (33.3%), pathological ultrasonography findings (22.0%), adverse pregnancy history (5.6%) and serological screening (5.1%).Conclusion NIPT is the most effective path screening for fetal chromosomal disease, high risk pregnant women must be diagnosed with invasive prenatal diagnosis. Serological triple screening and ultrasound examination are the most commonly used screening paths. Combined screening can effectively improve the detection rate of fetal chromosomal diseases, high risk full consultation after suggestions for invasive prenatal diagnosis. An independent indication of prenatal diagnosis is not an advanced age pregnant women, and invasive prenatal diagnosis is suggested if the high risk of serological screening or abnormal ultrasound is recommended.
黄林杰, 杨俐, 彭建红, 冯春, 徐丹, 刘娟, 张元珍, 马建鸿. 270例羊膜腔穿刺术产前诊断指征及结果分析[J]. 中国生育健康杂志, 2019, 30(3): 226-231.
HUANG Linjie, YANG li, PENG Jianhong, FENG chun, XU dan, LIU juan, ZHANG yuanzhen, MA Jianhong. Analysis on the Indications and results of amniocentesis in 270 cases. Chinese Journal of Reproductive Health, 2019, 30(3): 226-231.
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