Analysis of the effect of repetitive transcranial magnetic stimulation combined with Paroxetine Hydrochloride in the treatment of postpartum depression
WANG Zhen, JIANG Tianmei, LI Debo, SU Meihong, LUO Chunni.
Department of Obstetrics and Gynecology, Guangxi Zhuang Autonomous Region Brain Hospital,Liuzhou, 545000
Abstract：Objective To analyze the effect of repetitive transcranial magnetic stimulation (rTMS) combined with Paroxetine Hydrochloride in the treatment of postpartum depression . Methods Fifty patients with postpartum depression admitted to our hospital were selected from January 2017 to December 2017. Diagnostic criteria of postpartum depression was compliance with in the American Manual of Diagnosis and Statistics of Mental Diseases (4th edition). The objects were divided into observation group and control group with 25 cases in each by random number table method. The control group was treated with Paroxetine Combined with rTMS pseudo stimulation, while the observation group was treated with Paroxetine Combined with rTMS true stimulation. The dosage of paroxetine in both groups was 20 mg/d, and both groups were treated for 6 weeks. The postpartum depressive symptoms (EPDS scale) of two groups were compared before and after treatment, 1 weeks, 2 weeks, 4 weeks and 6 weeks after treatment and the levels of progesterone (P), estradiol (E2), treatment effect and adverse reaction were compared before and after treatment in the two groups. Results The EPDS score of the observation group was significantly lower than that of the control group (P<0.05) after 2, 4, 6 weeks of treatment. After treatment, the level of P and E2 in the observation group was significantly higher than that of the control group (P<0.05), and the total effective rate in the observation group was 96.0%, which was significantly higher than that in the control group(72.0%) (P<0.05), and the incidence of adverse reactions in the observation group was 24.0%, There was no significant difference between the control group and the control group (36.0%) (P>0.05). Conclusion Paroxetine hydrochloride combined with rTMS can significantly improve the depressive state of the patients with postpartum depression, improve the level of estrogen in the patients, improve the curative effect, and do not increase the adverse reaction.
王祯, 蒋天梅, 李德波, 苏梅红, 罗春妮. 重复经颅磁刺激联合盐酸帕罗西汀治疗产后抑郁的效果分析[J]. 中国生育健康杂志, 2020, 31(3): 219-222.
WANG Zhen, JIANG Tianmei, LI Debo, SU Meihong, LUO Chunni.. Analysis of the effect of repetitive transcranial magnetic stimulation combined with Paroxetine Hydrochloride in the treatment of postpartum depression. Chinese Journal of Reproductive Health, 2020, 31(3): 219-222.
