Abstract：Objective To study the postpartum glucose metabolism level, insulin resistance and pancreatic β cell function in gestational diabetes mellitus (GDM) patients, and to explore the high risk factors of postpartum glucose metabolism abnormality . Methods The postpartum blood glucose level, insulin use, postpartum insulin resistance and islet β cell function of 107 pregnant women with GDM diagnosed in our hospital from January 2012 to October 2018 were analyzed retrospectively and compared with those with normal blood glucose level. Results The insulin resistance index (IR) of GDM group with normal blood sugar level postpartum was higher than that of the reference group, the insulin sensitivity index (IS) and the modified β cell function index (MBCI) were lower than that of the reference group, the difference was statistically significant (P<0.05); the IR value of postpartum GDM group was significantly higher than that of postpartum reference group, the IR value of pre-postpartum GDM group was significantly higher than that of postpartum reference group (P<0.05); the IR value of postpartum GDM group was significantly higher than that of postpartum reference group. Compared with the normal postpartum group, the IS value in the pre-DM group was significantly lower than that in the postpartum GDM group (P<0.05). Compared with the group without insulin during pregnancy, the proportion of pre-diabetes and type 2 diabetes increased, the values of IR and MBCI increased, and the values of IS decreased in the use group (P<0.05). Conclusion The degree of insulin resistance of GDM pregnant women is more serious than that of normal pregnant women, and the function of islet β cell is worse than that of normal pregnant women. The more serious the abnormal situation of postpartum blood glucose is, the more severe the degree of insulin resistance is, the worse the function of islet β cell is, and the easier postpartum development of type 2 diabetes.
于成华, 张硕. 妊娠期糖尿病患者产后胰岛素抵抗及胰岛β细胞功能变化及其影响因素[J]. 中国生育健康杂志, 2020, 31(3): 215-218.
Yu Chenghua, Zhang Shuo.. Changes of postpartum insulin resistance and pancreatic β cell function in patients with gestational diabetes mellitus and its influencing factors. Chinese Journal of Reproductive Health, 2020, 31(3): 215-218.
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