1 Cecati M,Giannubilo SR,Saccucci F,et al.Potential Role of Placental Klotho in the Pathogenesis of Preeclampsia.Cell Biochem Biophys,2016,74:49-57. 2 Yuechi Xu,Zhongjie Sun.Molecular Basis of Klotho:From Gene to Function in Aging.Endocr Rev,2015,36:174-193. 3 Lin Y,Sun Z.In vivo pancreatic β-cell-specific expression of antiaging gene Klotho:a novel approach for preserving β-cells in type 2 diabetes.Diabetes,2015,64:1444-1458. 4 Lim K,Groen A,Molostvov G,et al.α-Klotho Expression in Human Tissues.J Clin Endocrinol Metab,2015,100:E1308-1318. 5 Kim JH,Hwang KH,Park KS,et al.Biological Role of Anti-aging Protein Klotho.J Lifestyle Med,2015,5:1-6. 6 Sopjani M,Rinnerthaler M,Kruja J,et al.Intracellular signaling of the aging suppressor protein Klotho.Curr Mol Med,2015,15:27-37. 7 Amitani M,Asakawa A,Amitani H,et al.Plasma klotho levels decrease in both anorexia nervosa and obesity.Nutrition,2013,29:1106-1109. 8 Inci A,Olmaz R,Sarl F,et al.Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels.Hippokratia,2016,20:198-203. 9 常晋瑞,孙娜,南瑛,等.Klotho的研究进展.生理科学进展,2015,46:245-249. 10 韩艳平,王佑民.代谢正常肥胖人群中 Klotho 蛋白与氧化应激相关性研究.安徽医科大学学报,2016,51:678-681. 11 Liu J J,Liu S,Morgenthaler N G,et al.Association of plasma soluble α-klotho with pro-endothelin-1 in patients with type 2 diabetes.Atherosclerosis,2014,233:415-418. 12 邵文佳,王冬雪,万庆宇,等.巨大儿胎盘组织中 Klotho mRNA和蛋白的表达及其与新生儿出生体质量的关系.中华妇产科杂志,2016,51:420-423. 13 Kim M,Paik J K,Kang R,et al.Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight / obese individuals.Metabolism,2013,62:554 - 560. 14 郭煜晖,胡大军,陈静,等.衰老相关基因Klotho的研究进展.中国老年学杂志,2017,37:759-761. 15 吴灿,王秋月,吕川,等.2 型糖尿病患者血清抗衰老蛋白 Klotho 的临床意义.中华糖尿病杂志,2015,7:177-181. 16 李爽,李子玲.血管内皮生长因子、Klotho 蛋白与 2 型糖尿病肾病的研究进展.北方药学,2014,11:56-57.