1 Dimitriades VR,Brown AG.Kawasaki disease:pathophysiology,clinical manifestations,and management.Curr Rheumatol Rep,2014,16:423. 2 Onouchi Y,Gunji T,Burns JC,et al.ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.Nat Genet,2008,40:35-42. 3 Onouchi Y,Suzuki Y,Suzuki H,et al.ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.Pharmacogenomics J,2013,13:52-59. 4 Onouchi Y,Ozaki K,Buns JC,et al.Common variants in CASP3 confer susceptibility to Kawasaki disease.Hum Mol Genet,2010,19:2898-2906. 5 Shimizu C,Jain S,Davila S,et al.Transforming Growth Factor-β Signaling pathway in patients with kawasaki disease clinical perspective.Circ Cardiovasc Genet,2011,4:16-25. 6 Ruizortega M,Rodríguezvita J,Sanchezlopez E,et al.TGF-β signaling in vascular fibrosis.Cardiovascular Res,2007,74:196-206. 7 Clark-Greuel JN,Connolly JM,Sorichillo E,et al.Transforming growth factor-beta1 mechanisms in aortic valve calcification:increased alkaline phosphatase and related events.Ann Thorac Surg 2007,83:946-953. 8 Tone Y,Furuuchi K,Kojima Y,et al.Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.Nat Immunol 2008,9:194-202. 9 Chang CJ,Kuo HC,Chang JS,et al.Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility.PLoS One,2013,8:e72037. 10 Urbich C,Dimmeler S.CD40 and vascular inflammation.Can J Cardiol,2004,20:681-683. 11 Li D,Liu L,Chen H,et al.LOX-1,an oxidized LDL endothelial receptor,induces CD40/CD40L signaling in human coronary artery endothelial cells.Arterioscler Thromb Vasc Biol,2003,23:816-821. 12 Chatzigeorgiou A,Lyberi M,Chatzilymperis G,et al.CD40/CD40L signaling and its implication in health and disease.Biofactors,2009,35:474-483. 13 Pamukcu B,Lip GY,Snezhitskiy V.The CD40-CD40L system in cardiovascular disease.Ann Med 2011,43:331-340. 14 Antoniades C,Bakogiannis C,Tousoulis D,et al.The CD40/CD40 ligand system:linking inflammation with atherothrombosis.J Am Coll Cardiol,2009,54:669-677. 15 Wang CL,Wu YT,Liu CA,et al.Expression of CD40 ligand on CD4+ T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease.Pediatrics,2003,111:E140-E147. 16 Burns JC,Glodé MP.Kawasaki syndrome.Lancet,2004,364:533-544. 17 Burdon KP,Langefeld CD,Beck SR,et al.Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS).Am Heart J,2006,151:706-711. 18 Kuo HC,Chao MC,Hsu YW,et al.CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population.Sci World J,2012:520-865. 19 Khor CC,Davila S,Breunis WB,et al.Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.Nat Genet,2011,43:1241-1246. 20 Kim JJ,Park YM,Yoon D,et al.Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis.J Hum Genet,2013,58:521-525. 21 Sun W,Li F S,Zhang Y H,et al.Association of susceptibility to septic shock with platelet endothelial cell adhesion molecule-1 gene Leu125Val polymorphism and serum sPECAM-1 levels in sepsis patients.Int J Clin Exp Med,2015,8:20490-20498. 22 Song Y,Li Q,Long L,et al.Asn563Ser polymorphism of CD31/PECAM-1 is associated with atherosclerotic cerebral infarction in a southern Han population,Neuropsychiatr Dis Treat,2015,11:15-20. 23 Xia T,Liu X,Du CJ,et al.Association of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heartdisease:a meta-analysis.Int J Clin Exp Med 2015,8:2219-2225. 24 Privratsky J R,Newman P J.PECAM-1:regulator of endothelial junctional integrity.Cell Tissue Res,2014,355:607-619. 25 Torzicky M,Viznerova P,Richter S,et al.Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) and CD99 are critical in lymphatic transmigration of human dendritic cells.J Invest Dermatol,2012,132:1149-1157. 26 Elrayess MA,Webb KE,Flavell DM,et al.A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies.Atherosclerosis 2003,168:131-138. 27 Elrayess MA,Webb KE,Bellingan GJ,et al.R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events.Atherosclerosis,2004,177:127-135. 28 Popovic′ D,Starevic′ JN,Letonja M,et al.PECAM-1gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus.Balkan J Med Genet,2016,19:63-70. 29 Shalia KK,Mashru MR,Soneji SL,et al.Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population.Indian J Clin Biochem 2010,25:273-279. 30 Robbins FM.CD31/PECAM-1 genotyping and haplotype analyses show population diversity.Tissue Antigens 2007,69:28-37. 31 Wei H,Fang L,Chowdhury SH,et al.Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with severe coronary artery stenosis in Chinese Singaporean.Clin Biochem 2004,37:1091-1097. 32 Fang L,Wei H,Chowdhury SH,et al.Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians.India J Med Res,2005,121:92-99. 33 Li Z,Han D,Jiang J,et al.Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children.Dis Markers 2017,2017:2960502. 34 Kim JJ,Yun SW,Yu JJ,et al.A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease.J Hum Genet,2017,62:1023-1029. 35 Onouchi Y,Ozaki K,Burns JC,et al.A genome-wide association study identifies three new risk loci for Kawasaki disease.Nat Genet,2012,44:517-521.
