1 Cornelison TL.Human papillomavirus genotype 16 vaccines forcervical cancer prophylaxis and treatment.Curr Opin Oncol,2000,12:466-473. 2 Ohta M,Inoue H ,Cotticelli MG,et al .The FHIT gene,spanning the chromosome 3p14.2 fragile site and renal carcinomaassociated t(3;8) breakpoint,is abnormal in digestive tract cancers.Cell,1996,84:587-597. 3 Greenspan DL,Connolly DC,Wu R,et al .Cho KR Loss of FHIT expression incervical carcinoma cell lines and primary tumors.Cancer Res,1997,57:4692-4698. 4 Ishii H,Dumon KR,Vecchione A,et al.Effect of adenovival transduction of the fragile histidine triad gene in the esophageal cancer cells.Cancer Res,2001,61:1578-1584. 5 Connolly DC,Greenspan DL,Wu R,ey al .Loss of fhit expression in invasivecervical carcinomas and intraepithelial lesions associated with invasivedisease.Clin Cancer Res,2000,6:3505-3510. 6 Butler D,Collins C,Mabruk M,et al .Deletion of the FHIT gene in neoplastic and invasive cervical lesions is relatedto high-risk HPV infection but is independent of histopathologicalfeatures.J Pathol,2000,192:502-510. 7 Nakagawa S,Yoshikawa H,Kimura M,et al.A possihie involvement of aberrant expreesion of the FHIT gene in the carcinorgensis of squanlous cell carcionma of the uterine cervix.Br J cancer,1999,79:589-594. 8 Huang LW,Chao SL,Chen TJ. Reduced Fhit expression in cervical carcinoma:correlation with tumor progression and poor prognosis.Gynecol Oncol,2003,90:331-337. 9 Machida S,Ohwada M,Saga Y,et al.Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor.Oncol,3003,65:89-94. 10 谢幸,苟文丽,主编.妇产科学.第8版.北京:人民卫生出版社,2013:409-413. 11 Giarnieri E,zanesi N Bottoni A,et al.Oocosuppresseor Proteins of fragile sites are reduced in cervical cancer.Cancer Letter.2010,289:40-45. 12 Jee SH,Won SY,Yun JE,et al.Polymorphism p53 codon-72 and invasive cervical cancer:a meta-analysis.Int J Gynaecol Obstet,2004,85:301-308. 13 Neyaz MK,Hussain S,Hassan MI,et al.Novel missense mutation in FHIT gene:interpreting the effectin HPV-mediated cervical cancer in Indian women.Mol Cell Biochem,2010,335:53-8. 14 Hu X,ZHANG Z,Ma D,et al.TP53,MDM2,NQO1,and susceptibility to cervical.Cancer Epidemiol Biomarkers Prev,2010,19:755-761. 15 Ueda M.Hung Y C,Terai Y,et al.Glutathione-S-transferase and p53 ploymorphisms in cercicalcarcinogensis.Gyncol Oncol,2005,96:736-740. 16 朱莉,王兴华.宫颈癌中FHIT基因的单核苷酸多态性表达.中国优生与遗产杂志,2010,18:31-33.
