乙肝病毒感染与男性精液参数及生殖激素水平的相关性分析

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (641 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨乙型肝炎病毒(HBV)感染对男性精液参数及血清生殖激素水平的影响。方法选择2017—2019年在本院生殖医学科进行辅助生殖治疗的228例男性患者,年龄25~45岁,按血清学乙肝表面抗原(HBsAg)检测结果分为HBV阳性组(76例)和HBV阴性组(152例)。结果 HBV阳性组精液常规参数与HBV阴性组相比,差异无统计学意义,但HBV阳性组精子浓度[75.4(46.4~111.8)×10⁶/mL]略低于HBV阴性组[85.4(50.6~135.6)×10⁶/mL]。HBV阳性组血清卵泡刺激素(FSH)水平[4.9(3.7~6.6)IU/L]高于HBV阴性组[4.0(3.0~5.7)IU/L],差异具有统计学意义。两组间卵泡刺激素与黄体生成素比值(FSH/LH)以及睾酮分泌指数(TSI)均无显著差异。结论 HBV携带者的血清FSH水平高于未感染者,HBV感染可能是损害男性生育健康的原因之一。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	陈巧媛
	杨洋
	辛志敏
	余兰
	宋蕊
	王丽
	王芹
	王晓杰
	王树玉

关键词 ：乙型肝炎病毒, 感染, 男性生殖, 精液参数, 生殖激素

收稿日期: 2020-09-06

ZTFLH:	R18
	R69
	R37

基金资助:首都医科大学附属北京妇产医院中青年学科骨干培养专项(FCYY201711)

通讯作者: 王树玉(yushu572000@126.com)

引用本文:

陈巧媛, 杨洋, 辛志敏, 余兰, 宋蕊, 王丽, 王芹, 王晓杰, 王树玉. 乙肝病毒感染与男性精液参数及生殖激素水平的相关性分析[J]. 中国生育健康杂志, 2022, 33(3): 270-272.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2022/V33/I3/270

1 Agarwal A,Mulgund A,Hamada A,et al.A unique view on male infertility around the globe.Reprod Biol Endocrinol,2015,13:37.
2 Schuppe HC,Pilatz A,Hossain H,et al.Urogenital infection as a risk factor for male infertility.Dtsch Arztebl Int,2017,114:339-346.
3 Neofytou E,Sourvinos G,Asmarianaki M,et al.Prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters.Fertil Steril,2009,91:2487-94.
4 Karamolahi S,Yazdi RS,Zangeneh M,et al.Impact of hepatitis B virus and hepatitis C virus infection on sperm parameters of infertile men.Int J Reprod Biomed (Yazd),2019,17:551-556.
5 Lorusso F,Palmisano M,Chironna M,et al.Impact of chronic viral diseases on semen parameters.Andrologia,2010,42:121-126.
6 Yakass MB,Woodward BJ,Otoo MA,et al.Prevalence of blood borne viruses in IVF:an audit of a fertility Centre.JBRA Assist Reprod,2016,20:132-136.
7 Bu Z,Kong H,Li J,et al.Effect of male hepatitis B virus infection on outcomes of in vitro fertilization and embryo transfer treatment:insights from couples undergoing oocyte donation.Int J Clin Exp Med,2014,7:1860-1866.
8 Keskin MZ,Budak S,Zeyrek T,et al.The relationship between serum hormone levels (follicle-stimulating hormone,luteinizing hormone,total testosterone) and semen parameters.Arch Ital Urol Androl,2015,87:194-197.
9 宋明哲,叶丽君,尹彪,等.精浆和血清生殖激素与精液质量的关系.生殖医学杂志,2016,25:341-346.
10 Zhou XL,Sun PN,Huang TH,et al.Effects of hepatitis B virus S protein on human sperm function.Hum Reprod,2009,24:1575-1583.
11 Villar LM,Cruz HM,Barbosa JR,et al.Update on hepatitis B and C virus diagnosis.World J Virol,2015,4:323-342.
12 Sikka SC,Hellstrom WJ.Current updates on laboratory techniques for the diagnosis of male reproductive failure.Asian J Androl,2016,18:392-401.
13 邢冠琳,王芳,柳胜贤,等.IUI助孕中男性乙肝病毒携带者精液质量分析.中国性科学,2015,24:94-96.
14 Landry D,Cloutier F,and Martin LJ.Implications of leptin in neuroendocrine regulation of male reproduction.Reprod Biol,2013,13:1-14.
15 Kong Y,Liu Y,Liu X,et al.Relationship between the mechanism of hepatitis B virus father-infant transmission and pregnancy outcome.Arch Gynecol Obstet,2017,295:253-257.