Association between periconceptional micronutrient supplementation and anemia in first trimester of gestational period
LI Sisi, LIU Chunyi, JIN Lei, JIAO Mingyuan, ZHANG Jie, MENG Wenying, JIN Lei
Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, Peking University, Beijing 100191, China
Abstract:Objective To investigate the prevalence of anemia in first trimester of gestational period among women in Tongzhou district of Beijing and evaluate the association between pure folic acid (PFA) or multiple micronutrients containing folic acid (MMFA) supplementation and the prevalence of anemia in first trimester. Methods The study was based on the information of 37 034 pregnant women in pregnancy health care system and the first-trimester laboratory system of Tongzhou Maternal and Child Health Hospital of Beijing during 2013 to 2018. Logistic regression model was used to analyze the relationship between status of PFA or MMFA consumption during periconceptional period and the risk of anemia in early pregnancy. Results The overall prevalence of anemia among the participants in first trimester of gestational period was 1.8%. Mild and microcytic hypochromic anemia were the predominant cases. Compared with women taking PFA, women taking MMFA had lower risk of overall anemia (aOR=0.79, 95% CI:0.66-0.95) and microcytic hypochromic anemia (aOR=0.69, 95% CI:0.53-0.91) in first trimester of gestational period. Among women who took MMFA, the women who started taking MMFA before pregnancy had lower risk of overall anemia (aOR=0.69, 95% CI:0.53-0.90) and microcytic hypochromic anemia (aOR=0.47, 95% CI:0.30-0.75) than those who started taking MMFA after pregnancy. Women who took MMFA frequently had lower risk of overall anemia (aOR=0.59, 95% CI:0.41-0.86) and microcytic hypochromic anemia (aOR=0.42, 95% CI:0.23-0.76) in first trimester of gestational period than those who did not take it. Among women taking MMFA, those who started taking it before pregnancy had higher serum iron levels (aβ=4.25, 95% CI:1.70-6.80). Conclusion The prevalence of anemia among pregnant women in first trimester of gestational period in Tongzhou district of Beijing was lower from 2013 to 2018. Periconceptional MMFA supplementation could reduce the risk of anemia in first trimester of gestational period, especially microcytic hypochromic anemia.
栗思思, 刘春毅, 金蕾, 焦明远, 张杰, 孟文颖, 靳蕾. 妇女围受孕期服用营养补充剂与孕早期贫血的关系[J]. 中国生育健康杂志, 2024, 35(2): 108-114.
LI Sisi, LIU Chunyi, JIN Lei, JIAO Mingyuan, ZHANG Jie, MENG Wenying, JIN Lei. Association between periconceptional micronutrient supplementation and anemia in first trimester of gestational period. Chinese Journal of Reproductive Health, 2024, 35(2): 108-114.
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