血清及胎盘中Siglec-6、Glycodelin-A水平与子痫前期发病和妊娠结局的相关性

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摘要目的探讨血清及胎盘中唾液酸结合免疫球蛋白样凝集素6(Siglec-6)、子宫糖基化蛋白(Glycodelin-A)水平与子痫前期发病和妊娠结局的相关性。方法选取2018年1月到2020年6月本院产科收治的子痫前期患者55例作为子痫前期组,年龄(30.1±3.3)岁,孕周(36.6±3.6)周,依据《妊娠期高血压疾病诊治指南(2020)》分为早发型子痫前期组21例,晚发型子痫前期34例;轻度子痫前期31例,重度子痫前期24例。同期分娩的正常孕妇55例作为对照组,年龄(29.6±2.8)岁,孕周(37.1±4.1)周。均为单胎初产妇,检测各组血清及胎盘中Siglec-6、Glycodelin-A水平。结果血清及胎盘中Siglec-6水平,子痫前期组明显高于对照组(P＜0.01),且重度子痫前期组显著高于轻度子痫前期组(P＜0.05),早发型子痫前期组明显高于晚发型子痫前期组(P＜0.05)。血清中及胎盘中Glycodelin-A水平,子痫前期组明显低于对照组(P＜0.05),且重度子痫前期组显著低于轻度子痫前期组(P＜0.05),早发型子痫前期组明显低于晚发型子痫前期组(P＜0.05)。子痫前期组血清及胎盘中Siglec-6与Glycodelin-A水平均呈负相关(P均<0.05),子痫前期组血清中Siglec-6水平与不良妊娠结局呈正相关(P<0.05),而Glycodelin-A水平与不良妊娠结局呈负相关(P<0.05)。结论血清及胎盘中Siglec-6、Glycodelin-A水平的变化在子痫前期发病及病情发展中起着重要作用,且和不良妊娠结局密切相关。

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	王晶
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关键词 ：唾液酸结合免疫球蛋白样凝集素6(Siglec-6), 子宫糖基化蛋白(glycodelin-A), 子痫前期, 妊娠结局

收稿日期: 2022-11-16

ZTFLH:

R714

通讯作者: 王晶(13141307059@163.com)

引用本文:

王晶, 王培萍, 张婕, 尚丽新. 血清及胎盘中Siglec-6、Glycodelin-A水平与子痫前期发病和妊娠结局的相关性[J]. 中国生育健康杂志, 2023, 34(6): 567-570.

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http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2023/V34/I6/567

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