血清中补体因子B、TLR4对妊娠期糖尿病患者发生子痫前期风险的预测价值

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摘要目的探讨血清中补体因子B、Toll样受体4(TLR4)对妊娠期糖尿病患者发生子痫前期风险的预测价值。方法 2022年5月至2023年5月,从本院就诊的妊娠期糖尿病患者中选取100例作为研究组,另选同期就诊的100例健康妊娠的患者作为对照组,对照组年龄为21～38岁,孕周为21～36周;研究组年龄为22～39岁,孕周为22～37周;研究组按照有无子痫前期分为无子痫前期组68例,有子痫前期组32例;按照子痫前期不同程度分为轻度组12例,中度组11例,重度组9例;检测血清补体因子B、TLR4水平,分析其与妊娠期糖尿病患者发生子痫前期的关系及其风险预测价值。结果与对照组相比,研究组血清中补体因子B、TLR4水平明显升高,组间差异有统计学意义;与无子痫前期组相比,有子痫前期组血清中补体因子B、TLR4水平明显升高,组间差异有统计学意义;与轻度组相比,中度组、重度组血清中补体因子B、TLR4水平明显升高,且重度组明显高于中度组,组间差异有统计学意义。二元Logistic回归分析显示,血清中补体因子B、TLR4均为妊娠期糖尿病患者发生子痫前期的风险因素;血清补体因子B检测的AUC为0.736,血清TLR4为0.697,联合为0.845。结论血清中补体因子B、TLR4是妊娠期糖尿病患者发生子痫前期的风险因素,对妊娠期糖尿病患者发生子痫前期具有预测价值。

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	陈晓雯
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关键词 ：补体因子B, TLR4, 妊娠期糖尿病, 子痫前期, 预测价值

收稿日期: 2023-09-13

ZTFLH:

R71

通讯作者: 段怡(yfychen2013@163.com)

引用本文:

陈晓雯, 段怡. 血清中补体因子B、TLR4对妊娠期糖尿病患者发生子痫前期风险的预测价值[J]. 中国生育健康杂志, 2024, 35(2): 162-165.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2024/V35/I2/162

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