子宫内膜容受性标记物与雌孕激素关系的研究进展

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中国生育健康杂志 ›› 2015, Vol. 26 ›› Issue (2) : 184-187.

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子宫内膜容受性标记物与雌孕激素关系的研究进展

梁琳, 陈秀娟

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摘要

在胚胎种植窗期,卵巢激素调节使子宫内膜形态结构和分泌蛋白均出现一系列变化,表现为胞饮突出,黏附分子、细胞因子、生长因子上调或下调,且与胚胎着床窗密切相关,使其成为子宫内膜容受性标记物。雌孕激素又从多方面影响子宫内膜的容受性。高水平的雌激素可导致黄体功能损害,造成胚胎发育和子宫内膜成熟不同步,降低对孕激素的反应。低雌激素又可使内膜种植窗开放时间延长。着床相关因子与雌孕激素的研究对改善子宫内膜容受性,确定“种植窗”,提高体外受精-胚胎移植(IVF-ET)妊娠率有重要作用。

关键词

体外受精-胚胎移植 / 内膜容受性 / 种植窗 / 白血病抑制因子 / 雌激素 / 孕激素

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梁琳, 陈秀娟. 子宫内膜容受性标记物与雌孕激素关系的研究进展[J]. 中国生育健康杂志, 2015, 26(2): 184-187

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