目的 探讨人绒毛膜促性腺素(HCG)注射日血清孕酮与新鲜周期辅助生殖孕妇产科结局的相关性。方法 收集2008年1月—2016年6月于我院接受取卵周期移植并分娩的634例单胎孕妇资料。按照是否发生产科结局(子痫前期、胎盘植入)进行分组,分别为病例组和对照组,其中,子痫前期24例,非子痫前期610例;胎盘植入29例,非胎盘植入605例。采用Logistic回归分析HCG注射日血清孕酮与产科结局的关系。结果 胎盘植入组血清孕酮和HCG注射日血清雌二醇均显著高于对照组 (P=0.007,P=0.038)。多因素分析孕酮增加胎盘植入发生风险(OR=1.397,95%CI 1.093~1.784,P=0.007)。血清孕酮水平与子痫前期发生的关系无统计学意义。结论 HCG注射日血清孕酮升高,新鲜周期辅助生殖单胎孕妇胎盘植入发生风险增高;与子痫前期发生无相关性。
关键词
HCG注射日 /
血清孕酮 /
子痫前期 /
胎盘植入
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参考文献
1 Nikolettos N,Asimakopoulos B,Koster F,et al.Cytokine profile in cases with premature elevation of progesterone serum concentrations during ovarian stimulation.Physiol Res,2008,57:215-224.
2 颜建英,吴新枝,张勤建.血管内皮生长因子和胎盘微血管密度与胎盘植入发病的关系.中华围产医学杂志,2016,19:608-613.
3 Schindler AE.Present and future aspects of dydrogesterone in prevention or treatment of pregnancy disorders:an outlook.Horm Mol Biol Clin Investig,2016,27:49-53.
4 Irving C,Hertig AT.A study of placenta accreta.Surg Gynecol Obstet,1937,64:178-200.
5 Albrecht ED,Bonagura TW,Burleigh DW,et al.Suppression of extravillous trophoblast invasion of uterine spiral arteries by estrogen during early baboon pregnancy.Placenta,2006,27:483-490.
6 Boroujeni MB,Boroujeni NB,Gholami M.The effect of progesterone treatment after ovarian induction on endometrial VEGF gene expression and its receptors in mice at pre-implantation time.Iran J Basic Med Sci,2016,19:252-257.
7 Tseng JJ,Chou MM.Differential expression of growth-,angiogenesis- and invasion-related factors in the development of placenta accreta.Taiwan J Obstet Gynecol,2006,45:100-106.
8 Chantraine F,Blacher S,Berndt S,et al.Abnormal vascular architecture at the placental-maternal interface in placenta increta.Am J Obstet Gynecol,2012,207:181-188.
9 Choux C,Carmignac V,Bruno C,et al.The placenta:phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy.Clin Epigenetics,2015,7:87.
10 Kim SC,Park MJ,Joo BS,et al.Decreased expressions of vascular endothelial growth factor and visfatin in the placental bed of pregnancies complicated by preeclampsia.J Obstet Gynaecol Res,2012,38:665-673.
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