Abstract:Objective To explore the association between exposure to organochlorine pesticides (OCPs) during early pregnancy and gestational diabetes (GDM).Methods We conducted a nested case-control study based on a birth cohort. From June 2018, 200 GDM pregnant women (i.e., the case group) were randomly selected from a prospective cohort (PKUBC-T birth cohort) established in the Maternal and Child Health Hospital of Tongzhou District, Beijing City. The GDM women were 1:1 matched with 200 healthy pregnant women (i.e., the control group), according to the gestational age and time of OGTT. The basic information of pregnant women was collected by questionnaires during the first visit of prenatal care. Samples of venous blood was collected from the pregnant women during their first trimester, and 20 OCPs concentrations in plasma were quantified by gas chromatography-mass spectrometry. We utilized conditional logistic regression to examine whether the OCPs concentrations in the control group were different from those in the GDM cases.Results Five out of twenty OCPs were detected. The highest detection rate (100.00%) was reported for 2,2-bis(4-chlorophenyl)-1,1-dichloroethene (p,p′-DDE). Among the five detected OCPs, the highest was the concentration of Endrin (END), the median of which was 232.4 ng/g lipid and 201.1 ng/g lipid for the GDM cases and the controls, respectively; the second was p,p′-DDE, the median of which was 63.9 ng/g lipid and 56.2 ng/g lipid for the GDM cases and the controls, respectively. After adjustment for multiple covariates, the association between END and GDM was statistically significant (OR=1.84, 95%CI:1.01-3.34; for the high-exposure group, referring to the low-exposure group). We also found a dose-response relationship between END and GDM.Conclusion Among the 5 OCPs detected in the early-pregnant women in Beijing, we found that the exposure to END was a risk factor for the development of GDM. We didn′t find significant correlation between GDM the other four OCPs.
杨向明, 韩娜, 包鹤龄, 金楚瑶, 周双, 徐金辉, 王斌, 王海俊, 安琳. 妊娠早期有机氯农药暴露与妊娠期糖尿病的关联研究[J]. 中国生育健康杂志, 2022, 33(3): 201-205.
YANG Xiangming, HAN Na, BAO Heling, JIN Chuyao, ZHOU Shuang, XU Jinhui, WANG Bin, WANG Haijun, AN Lin. The association between organochlorine pesticide exposure in early pregnancy and gestational diabetes. Chinese Journal of Reproductive Health, 2022, 33(3): 201-205.
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