Influence of SARS-CoV-2 infection on delivery mode among pregnant women
LI Zewu, SUN Guoqiang, ZHAO Yun, FAN Cuifang, CHEN Huijun, FENG Ling, SHEN Jian, XIA Geqing, CHEN Hui, WANG Bin, LI Zhiwen
Institute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Abstract:Objective To describe the current status of different delivery modes among pregnant women during the COVID-19 pandemic and to investigate the influence of SARS-CoV-2 infection on delivery mode.Methods This study was a retrospective cohort study built in Wuhan between May and September, 2020. Three groups of pregnant women had been recruited in this cohort including:127 pregnant women who were confirmed to infect with SARS-CoV-2, 255 pregnant women who were preciously suspected to infect with SARS-CoV-2 and 515 uninfected pregnant women. The total effect of SARS-CoV-2 infection and its secondary effect (including influence on mental, lifestyle etc.) was explored by comparing the status of delivery mode in confirmed group and uninfected group. The specific effect of SARS-CoV-2 virus itself was explored by comparing the status of delivery mode in confirmed group and previously suspected group.Results The prevalence of caesarean section in confirmed group, previously suspected group and uninfected group were 74.0%, 73.3% and 55.5%. In multivariate model, the SARS-CoV-2 infection(PR:1.36, 95%CI:1.19-1.54) and previously suspected infection(PR:1.24, 95%CI:1.11-1.39) were associated with caesarean section when uninfected group was taken as the inference group; the SARS-CoV-2 infection(PR:1.09, 95%CI:0.96-1.24) was not associated with caesarean section.Conclusions ARS-CoV-2 confirmed infection and previously suspected infection may increase the risk of caesarean section, and the lack of knowledge of SARS-CoV-2 and medical facilities may be the potential reason of the increase.
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