目的 探讨血管内皮细胞生长因子A(VEGFA)基因多态性与小于胎龄儿(SGA)易感性。方法 采用巢氏病例对照研究设计,选取2013年5月到2014年9月马鞍山优生优育队列中分娩SGA的母亲183例和分娩适于胎龄儿(AGA)的母亲298例。对母血VEGFA基因上7个功能性位点(rs2010963、rs833061、rs10434、rs1570360、rs3025020、rs3025040、rs3025053)进行基因分型。应用多因素Logistic回归法分析不同遗传模型下各位点与SGA发病风险之间的相关性。结果 多因素Logistic回归分析显示,调整母亲年龄、文化程度、吸烟、饮酒及家庭月收入后,与VEGFA rs2010963 CC基因型携带者相比,GC基因型(OR=1.94,95% CI=1.12～3.35)和G等位基因携带者(OR=1.69,95% CI=1.01～2.83)分娩SGA的风险显著增加。进一步控制母亲孕前BMI和父亲BMI后,以上结果仍有显著性。但经错误发现率(FDR)校正后,显著性消失。结论 携带VEGFA rs2010963 G等位基因的孕妇分娩SGA的风险是否增高需要更大样本的验证。
关键词
小于胎龄儿(SGA) /
遗传多态性 /
血管内皮细胞生长因子A(VEGFA)
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中图分类号：
R17
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参考文献
1 Nam HK,Lee KH.Small for gestational age and obesity:epidemiology and general risks.Ann Pediatr Endocrinol Metab,2018,23:9-13.
2 Hong YH,Chung S.Small for gestational age and obesity related comorbidities.Ann Pediatr Endocrinol Metab,2018,23:4-8.
3 Wang XY,Sun T,Chen GC,et al.Association between Vascular Endothelial Growth Factor Gene Polymorphisms and Pre-Eclampsia Susceptibility:An Updated Meta-Analysis.Immunol Invest,2020,49:120-133.
4 Al Balawi IA,Mir R,Abu-Duhier FM Potential impact of vascular endothelial growth factor gene variation (-2578C>A) on breast cancer susceptibility in saudi arabia:a case-control study.Asian Pac J Cancer Prev,2018,19:1135-1143.
5 Andraweera PH,Dekker GA,Thompson SD,et al.Association of vascular endothelial growth factor +936 C/T single-nucleotide polymorphism with pregnancies complicated by small-gestational-age babies.Arch Pediatr Adolesc Med,2011,165:1123-1130.
6 Anand S,Mehrotra S,Singh U,et al.Study of association of fetal cerebroplacental ratio with adverse perinatal outcome in uncomplicated term AGA pregnancies.J Obstet Gynaecol India,2020,70:485-489.
7 García-Closas M,Lubin JH.Power and sample size calculations in case-control studies of gene-environment interactions:comments on different approaches.Am J Epidemiol,1999,149:689-692.
8 Bányász I,Bokodi G,Vásárhelyi B,et al.Genetic polymorphisms for vascular endothelial growth factor in perinatal complications.Eur Cytokine Netw,2006,17:266-270.
9 Chen XZ,Yu SJ,Wei MH,et al.Effects of maternal and fetal vascular endothelial growth factor single nucleotide polymorphisms on pre-eclampsia:A hybrid design study.Cytokine,2020,127:154995.
10 Bányász I,Szabó S,Bokodi G,et al.Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsia.Mol Hum Reprod,2006,12:233-236.
11 Amosco MD,Villar VA,Naniong JM,et al.VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population.Clin Exp Hypertens,2016,38:578-585.
12 Ben AliGannoun M,Al-Madhi SA,Zitouni H,et al.Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia:A case-control study.Cytokine,2017 ,97:175-180.
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脚注
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基金
安徽医科大学2016年度博士科资助(XJ201620)
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