目的 探讨血清及胎盘中唾液酸结合免疫球蛋白样凝集素6(Siglec-6)、子宫糖基化蛋白(Glycodelin-A)水平与子痫前期发病和妊娠结局的相关性。方法 选取2018年1月到2020年6月本院产科收治的子痫前期患者55例作为子痫前期组,年龄(30.1±3.3)岁,孕周(36.6±3.6)周,依据《妊娠期高血压疾病诊治指南(2020)》分为早发型子痫前期组21例,晚发型子痫前期34例;轻度子痫前期31例,重度子痫前期24例。同期分娩的正常孕妇55例作为对照组,年龄(29.6±2.8)岁,孕周(37.1±4.1)周。均为单胎初产妇,检测各组血清及胎盘中Siglec-6、Glycodelin-A水平。结果 血清及胎盘中Siglec-6水平,子痫前期组明显高于对照组(P＜0.01),且重度子痫前期组显著高于轻度子痫前期组(P＜0.05),早发型子痫前期组明显高于晚发型子痫前期组(P＜0.05)。血清中及胎盘中Glycodelin-A水平,子痫前期组明显低于对照组(P＜0.05),且重度子痫前期组显著低于轻度子痫前期组(P＜0.05),早发型子痫前期组明显低于晚发型子痫前期组(P＜0.05)。子痫前期组血清及胎盘中Siglec-6与Glycodelin-A水平均呈负相关(P均<0.05),子痫前期组血清中Siglec-6水平与不良妊娠结局呈正相关(P<0.05),而Glycodelin-A水平与不良妊娠结局呈负相关(P<0.05)。结论 血清及胎盘中Siglec-6、Glycodelin-A水平的变化在子痫前期发病及病情发展中起着重要作用,且和不良妊娠结局密切相关。
关键词
唾液酸结合免疫球蛋白样凝集素6(Siglec-6) /
子宫糖基化蛋白(glycodelin-A) /
子痫前期 /
妊娠结局
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中图分类号：
R714
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参考文献
1 Roberts JM,Rich-Edwards JW,McElrath TF,et al.Subtypes of Preeclampsia:Recognition and Determining Clinical Usefulness.Hypertension,2021,77:1430-1441.
2 Simard JF,Rossides M,Wikström AK,et al.Evidence of under-reporting of early-onset preeclampsia using register data.Paediatr Perinat Epidemiol,2021,35:596-600.
3 Ives CW,Sinkey R,Rajapreyar I,et al.Preeclampsia-Pathophysiology and Clinical Presentations:JACC State-of-the-Art Review.J Am Coll Cardiol,2020,76:1690-1702.
4 Collier AY,Smith LA,Karumanchi SA.Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy.Hum Immunol,2021,82:362-370.
5 Jetani H,Navarro-Bailón A,Maucher M,et al.Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia.Blood,2021,138:1830-1842.
6 Awoyemi T,Tannetta D,Zhang W,et al.Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas.Biochem Biophys Res Commun,2020,533:838-844.
7 Lee CL,Lam KK,Vijayan M,et al.The Pleiotropic Effect of Glycodelin-A in Early Pregnancy.Am J Reprod Immunol,2016,75:290-297.
8 Löb S,Vattai A,Kuhn C,et al.Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA).J Reprod Immunol,2021,143:103267.
9 杨孜,张为远.妊娠期高血压疾病诊治指南(2020).中华妇产科杂志,2020,55:227-238.
10 Rumer KK,Uyenishi J,Hoffman MC,et al.Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia.Reprod Sci,2013,20:646-653.
11 李红梅.早发型重度子痫前期合体滋养细胞外囊泡的差异蛋白质组学研究.第三军医大学,重庆,2016:1-109.
12 Tarca AL,Romero R,Benshalom-Tirosh N,et al.The prediction of early preeclampsia:Results from a longitudinal proteomics study.PLoS One,2019,14:e0217273.
13 Hautala LC,Pang PC,Antonopoulos A,et al.Altered glycosylation of glycodelin in endometrial carcinoma.Lab Invest,2020,100:1014-1025.
14 Dixit A,Balakrishnan B,Karande AA.Immunomodulatory activity of glycodelin:implications in allograft rejection.Clin Exp Immunol,2018,192:213-223.
15 Lee CL,Lam KK,Koistinen H,et al.Glycodelin-A as a paracrine regulator in early pregnancy.J Reprod Immunol,2011,90:29-34.
16 Lee CL,Vijayan M,Wang X,et al.Glycodelin-A stimulates the conversion of human peripheral blood CD16-CD56bright NK cell to a decidual NK cell-like phenotype.Hum Reprod,2019,34:689-701.
17 Lam KK,Chiu PC,Lee CL,et al.Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.J Biol Chem,2011,286:37118-37127.
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