X染色体非整倍体嵌合对体外受精胚胎移植助孕妊娠结局的影响

李丹, 焦利萍, 高雪峰, 李蓉, 迟洪滨

中国生育健康杂志 ›› 2024, Vol. 35 ›› Issue (6) : 561-565.

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中国生育健康杂志 ›› 2024, Vol. 35 ›› Issue (6) : 561-565.
论著

X染色体非整倍体嵌合对体外受精胚胎移植助孕妊娠结局的影响

  • 李丹, 焦利萍, 高雪峰, 李蓉, 迟洪滨
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摘要

目的 探讨X染色体非整倍体嵌合对接受体外受精胚胎移植(IVF/ICSI)助孕患者妊娠结局的影响。方法 采用回顾性研究方法,收集83 对女方存在X染色体非整倍体嵌合的夫妇资料,根据异常核型嵌合比例不同分为<10%组(71例)和>10%组(12例),以1∶2匹配166对染色体正常的夫妇,统计嵌合比例<10%组和嵌合比例>10%两组病例在体外受精胚胎移植患者(IVF-ET)中的年龄、身高、BMI、不孕原因、不孕年限、基础内分泌值、双侧窦卵泡数、 IVF用药方案、当周期移植率、周期取消率、当周临床妊娠率、持续妊娠率和流产率。结果 两个嵌合组与正常对照组的临床妊娠率没有显著性差异,而X染色体非整倍体嵌合的女性,嵌合比例<10%的低比例嵌合组其流产率显著高于对照组,活婴分娩率显著低于对照组。结论 X染色体非整倍体嵌合比例<10%的低比例嵌合的女性在妊娠过程中增加了流产的风险。

关键词

性染色体 / 低比例嵌合 / 流产 / 体外受精胚胎移植(IVF-ET)

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李丹, 焦利萍, 高雪峰, 李蓉, 迟洪滨. X染色体非整倍体嵌合对体外受精胚胎移植助孕妊娠结局的影响[J]. 中国生育健康杂志, 2024, 35(6): 561-565
中图分类号: R71   

参考文献

1 谢幸,孔北华,段涛,主编.妇产科学.第9版.北京:人民卫生出版社,2019:361.
2 Sonntag B,Meschede D,Ullmann V,et al.Low-level sex chromosome mosaicism in female partners of couples undergoing ICSI therapy does not significantly affect treatment outcome.Hum Reprod,2001,16:1648-1652.
3 Meschede D,Lemcke B,Exeler JR,et al.Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection-prevalence,types,sex distribution and reproductive relevance.Hum Reprod,1998,13:576-582.
4 Morel F,Gallon F,Amice V,et al.Sex chromosome mosaicism in couples undergoing intracytoplasmic sperm injection.Hum Reprod,2002,17:2552-2555.
5 Otter M,Schrander-Stumpel CT,Curfs LM.Triple X syndrome:a review of the literature.Eur J Hum Genet,2010,18:265-271.
6 Peschka B,Leygraaf J,Van der Ven K,et al.Type and frequency of chromosome aberrations in 781 couples undergoing intracytoplasmic sperm injection.Hum Reprod,1999,14:2257-2263.
7 Gekas J,Thepot F,Turleau C,et al.Chromosomal factors of infertility in candidate couples for ICSI:an equal risk of constitutional aberrations in women and men.Hum Reprod,2001,16:82-90.
8 Zachaki S,Kouvidi E,Pantou A,et al.Low-level X Chromosome Mosaicism:A Common Finding in Women Undergoing IVF.In Vivo,2020,34:1433-1437.
9 Guttenbach M,Koschorz B,Bernthaler U,et al.Sex chromosome loss and aging:in situ hybridization studies on human interphase nuclei.Am J Hum Genet,1995,57:1143-1150.
10 Eds Shaffer LG & Tommerup N.ISCN.An International System for Human Cytogenetic Nomenclature.Basel Switzerland:S.Karger,2005.
11 Nowinski GP,Van Dyke DL,Tilley BC,et al.The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.Am J Hum Genet,1990,46:1101-1111.
12 Guttenbach M,Koschorz B,Bernthaler U,et al.Sex chromosome loss and aging:in situ hybridization studies on human interphase nuclei.Am J Hum Genet,1995,57:1143-1150.
13 Hassold T,Merrill M,Adkins K,et al.Recombination and maternal age-dependent nondisjunction:molecular studies of trisomy 16.Am J Hum Genet,1995,57:867-874.
14 Sherman SL,Petersen MB,Freeman SB,et al.Non-disjunction of chromosome 21 in maternal meiosis I:evidence for a maternal age-dependent mechanism involving reduced recombination.Hum Mol Genet,1994,3:1529-1535.
15 Petersen MB,Mikkelsen M.Nondisjunction in trisomy 21:origin and mechanisms.Cytogenet Cell Genet,2000,91:199-203.
16 Gersak K,Veble A.Low-level X chromosome mosaicism in women with sporadic premature ovarian failure.Reprod Biomed Online,2011,22:399-403.
17 Bakalov VK,Cooley MM,Quon MJ,et al.Impaired insulin secretion in the Turner metabolic syndrome.J Clin Endocrinol Metab,2004,89:3516-3520.
18 Homer L,Le Martelot MT,Morel F,et al.45,X/46,XX mosaicism below 30% of aneuploidy:clinical implications in adult women from a reproductive medicine unit.Eur J Endocrinol,2010,162:617-623.
19 Gersak K,Veble A.Low-level X chromosome mosaicism in women with sporadic premature ovarian failure.Reprod Biomed Online,2011,22:399-403.
20 LYON MF.Gene action in the X-chromosome of the mouse (Mus musculus L.).Nature,1961,190:372-373.
21 Cimadomo D,Fabozzi G,Vaiarelli A,et al.Impact of Maternal Age on Oocyte and Embryo Competence.Front Endocrinol (Lausanne),2018,9:327.
22 Kuo PL,Guo HR.Mechanism of recurrent spontaneous abortions in women with mosaicism of X-chromosome aneuploidies.Fertil Steril,2004,82:1594-1601.
23 Burgoyne PS,Baker TG.Meiotic pairing and gametogenic failure.Symp Soc Exp Biol,1984,38:349-362.
24 Capalbo A,Rienzi L,Cimadomo D,et al.Correlation between standard blastocyst morphology,euploidy and implantation:an observational study in two centers involving 956 screened blastocysts.Hum Reprod,2014,29:1173-1181.

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