广东省双胎新生儿胎龄别出生体重百分位数曲线研究

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摘要目的建立广东省双胎活产新生儿的胎龄别出生体重百分位数曲线。方法利用广东省2014—2016年的出生证资料中性别、胎龄、是否同卵及出生体重数据,采用GAMLSS方法建立不同性别间单卵双生及双卵双生新生儿的出生体重百分位数曲线。结果从2014年到2016年,广东省双胎活产新生儿的平均出生体重由(2 447.6±3.0)g降至(2 403.1±2.9)g,早产率由40.6%上升至45.6%,单卵双生新生儿及双卵双生新生儿男女性别、平均出生体重、早产率、低出生体重率的差异有统计学意义;得到广东省单卵双生及双卵双生的25～43孕周的3rd、10th、25th、50th、75th、90th、95th出生体重参考值及曲线,双卵双胎男婴、双卵双胎女婴、单卵双胎男婴及单卵双胎女婴儿平均出生体重增长最快分别在35周、34周、32周及36周,每周增长数值约为197～208 g。结论本研究建立符合广东省地区特点的不同胎龄双胞胎同卵双生和异卵双生的出生体重标准,可使本地区的双胞胎出生体重参考值范围更趋精准,尤其可为临床医生识别高危双胎及评估双胎发育情况提供依据。

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	姚菲
	缪华章
	祝新红
	陈水莲
	董青青
	吴云涛
	李兵
	赵庆国

关键词 ：出生体重, 生长曲线, 百分位数, 双胎

Abstract：Objective To establish the percentile curve of birth weight by gestational age for twins in Guangdong province. Methods By using GAMLSS method, birth weight percentile curves of twins with different genders were established by using birth certificate data from 2014 to 2016 of Guangdong Province. The following variables were extracted and analyzed:the sex of infants, gestational age, placental chorionicity, and birth weight. Results The average birth weight decreased from 2 447.6±3.0 g in 2014 to 2 403.1±2.9 g in 2016, and the preterm birth rate increased from 40.6% in 2014 to 45.6% in 2016. There was significant difference in the mean birth weight, preterm birth rate, and low birth weight rate between the dichorionic diamniotic twins (DCDA) and the monochrionic diamniotic twins (MCDA). The reference curves of birth weight were generated, and the corresponding reference values of the 3rd, 10th, 25th, 50th, 75th, 90th, and 95th percentiles were provided for infants delivered between 25 and 43 weeks of gestation for DCDA and MCDA, respectively. For the male of DCDA, the female of DCDA, the male of MCDA, and the female of MCDA, the fastest growth rate in birth weight occurred in 35, 34, 32, and 36 weeks, respectively, ranging from 197 to 208 g. Conclusion The standard curve of birth weight of twins with different gestational age is established for both DCMA and MCDA in Guangdong province, which can make the estimation of twins’ birth weight more accurate in this area, and will provide a regional reference for clinicians to evaluate the growth status of twins.

Key words： birth weight growth curve percentile twins

收稿日期: 2017-07-03

通讯作者: 赵庆国(zqgfrost@126.com)

引用本文:

姚菲, 缪华章, 祝新红, 陈水莲, 董青青, 吴云涛, 李兵, 赵庆国. 广东省双胎新生儿胎龄别出生体重百分位数曲线研究[J]. 中国生育健康杂志, 2018, 29(2): 126-133.
YAO Fei, MIAO Huazhang, ZHU Xinhong, CHEN Shuilian, DONG Qingqing, WU Yuntao, LI Bing, ZHAO Qingguo. Birth weight percentiles curve by gestational age for twins born in Guangdong Province. Chinese Journal of Reproductive Health, 2018, 29(2): 126-133.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2018/V29/I2/126

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